Evidence map›Paper›PMID 41349782›Full record

ArticleExperimental eye research2026

The effect of age on wound healing in the laser induced choroidal neovascularization model.

William F Horrigan, Quinn Caron, Aidan Rodriguez, Rupesh Singh, Bela Anand-Apte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

William F HorriganDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH, USA.
Quinn CaronDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, USA; Dept. of Pharmacology, Biomedical Sciences Training Program, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, USA.
Aidan RodriguezDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, USA.
Rupesh SinghDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, USA.
Bela Anand-ApteDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH, USA. Electronic address: anandab@ccf.org.

Funding

RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI BELA ANAND-APTE · 2016 to 2026
$7.7M
Regulation of Choroidal Neovascularization in Sorsby's Fundus DystrophyR01EY027083 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2017 to 2024
$4.0M
Molecular Medicine Training Program at Cleveland Clinic/Case Western Reserve UniversityT32GM137868 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI Justin D. Lathia, Jonathan D Smith · 2021 to 2026
$2.0M
Role of TIMP-3 in Ocular NeovascularizationR01EY016490 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2005 to 2009
$1.7M
Role of betacellulin in diabetic macular edemaR01EY020861 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2011 to 2014
$1.5M
Cole Eye Institute Vision Science Training ProgramT32EY024236 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2015 to 2025
$1.0M
NEI NIH HHS P30 EY025585NEI NIH HHS R01 EY016490NEI NIH HHS R01 EY020861NEI NIH HHS R01 EY027083NEI NIH HHS T32 EY024236NIGMS NIH HHS T32 GM137868
6 · The paper itself

Abstract

The laser induced model of choroidal neovascularization (LiCNV) is a commonly used in vivo rodent model to study neovascular age-related macular degeneration (nAMD), although progression of this model is not well understood. In this study we characterize and compare the longitudinal progression of wound healing of laser induced choroidal neovascular (CNV) lesions in young and old mice. Using 2-month and 12-month-old C57BL/6J mice and ocular computerized tomography (OCT), fluorescein and indocyanine green angiography we performed a longitudinal imaging analysis at 3-, 7-, 14- and 28-days following laser injury. This was compared with immunohistochemical analysis of the lesions at similar timepoints for markers of angiogenesis, fibrosis, epithelial-to-mesenchymal transition (EMT), and gliosis. OCT analysis determined an increased lesion volume in older mice. In contrast younger mice demonstrated earlier vascularization and fibrosis with no difference in neovascularization or leakage. Reactive gliosis occurs directly above the laser-induced CNV lesion in both ages. The RPE in this model encloses the lesion area by day 14 in both young and old mice. This study concludes that age is an important variable in some but not all aspects of laser-induced CNV.

Indexed as

AgingChoroidal NeovascularizationDisease Models, AnimalWound HealingAnimalsChoroidEpithelial-Mesenchymal TransitionFibrosisFluorescein AngiographyGliosisIndocyanine GreenLaser CoagulationMiceMice, Inbred C57BLTomography, Optical CoherenceTomography, X-Ray ComputedIndocyanine GreenLaser induced choroidal neovascularizationNeovascular AMDSubretinal fibrosisWound healing

Identifiers

PMID41349782
PMCPMC12782133

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.