Evidence map›Paper›PMID 41349545›Full record

ArticleCell2026

Renal PIEZO2 is an essential regulator of renin.

Rose Z Hill, Jonathan W Nelson, Georgina Gyarmati, Silvia Medrano, Sepenta Shirvan, James A McCormick, Sebastian Burquez, Jeanine Ahmed, Diana G Eng, Jan Wysocki and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Rose Z HillHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: hillros@ohsu.edu.
Jonathan W NelsonDivision of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Georgina GyarmatiDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Silvia MedranoDepartment of Pediatrics, University of Virginia School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Sepenta ShirvanHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
James A McCormickDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
Sebastian BurquezHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Jeanine AhmedHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Diana G EngDivision of Nephrology, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Jan WysockiDivision of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Adrienne E DubinHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
M Rocio Servin-VencesHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Arjun LakshmananDivision of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
R Ariel GomezDepartment of Pediatrics, University of Virginia School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Maria Luisa S Sequeira-LopezDepartment of Pediatrics, University of Virginia School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
Stuart J ShanklandDivision of Nephrology, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Daniel BatlleDivision of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jeffrey H MinerDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Janos Peti-PeterdiDivision of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Ardem PatapoutianHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: ardem@scripps.edu.

Funding

Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI PATRICIO E. RAY · 2012 to 2026
$13.8M
Multiphoton Imaging of the Juxtaglomerular ApparatusR01DK064324 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JANOS PETI-PETERDI · 2004 to 2026
$8.4M
Juxta-glomerular cells serve as glomerular epithelial cell progenitors in glomerular diseaseR01DK097598 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES, WESSELY, OLIVER · 2014 to 2022
$5.2M
Renin cell identity and blood pressure homeostasisR01HL148044 · NHLBI · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2020 to 2023
$2.7M
Revealing New Therapeutic Opportunities for Kidney Glomerular Diseases by Elucidating the Mechanobiological Functions of Novel Cytoskeletal Structures in PodocytesR01DK141178 · NIDDK · WASHINGTON UNIVERSITY · PI Guy M Genin, JEFFREY H MINER · 2024 to 2026
$2.4M
Innovative Approaches to Treating Alport SyndromeR01DK128660 · NIDDK · WASHINGTON UNIVERSITY · PI MINER, JEFFREY H · 2021 to 2025
$2.2M
Magnesium handling by the distal nephronR01DK132066 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI JAMES A MCCORMICK · 2023 to 2026
$1.3M
Renal Pericytes as a Target for Angiotensin II Signaling in HypertensionK01DK121737 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NELSON, JONATHAN W · 2020 to 2024
$669k
Multiphoton microscope replacement for USC shared resourceS10OD021833 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PETI-PETERDI, JANOS · 2017 to 2017
$600k
Functional interrogation of sensory neurons in inflammationR00NS133478 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Rose Z Hill · 2025 to 2026
$495k
Functional interrogation of sensory neurons in inflammationK99NS133478 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI HILL, ROSE Z · 2023 to 2024
$240k
Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL148044NIDDK NIH HHS K01 DK121737NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK064324NIDDK NIH HHS R01 DK097598NIDDK NIH HHS R01 DK128660NIDDK NIH HHS R01 DK132066NIDDK NIH HHS R01 DK141178NIH HHS S10 OD021833NINDS NIH HHS K99 NS133478NINDS NIH HHS R00 NS133478
6 · The paper itself

Abstract

Renin synthesis and release is the rate-limiting step of the renin-angiotensin-aldosterone system (RAAS) that controls fluid homeostasis. A major activator of the RAAS is a decrease in perfusion pressure within the kidneys, suggesting a link between renal mechanotransduction and renin. However, the identity of the mechanosensor(s) in the kidneys and their physiological significance to the RAAS remain unclear. We find that loss of the force-gated nonselective cation channel PIEZO2 in cells of renin lineage dysregulates the RAAS by elevating renin. We observe that PIEZO2 is expressed in renin-producing juxtaglomerular granular cells and is required for their calcium dynamics in vivo. PIEZO2 deficiency in cells of renin lineage drives renin-dependent and MAS-receptor-dependent glomerular hyperfiltration and regulates the RAAS during acute and chronic blood volume challenges. Collectively, our study identifies PIEZO2 as an essential regulator of juxtaglomerular granular cell calcium activity and renin in vivo.

Indexed as

Ion ChannelsKidneyReninAnimalsCalciumJuxtaglomerular ApparatusMaleMechanotransduction, CellularMiceMice, Inbred C57BLMice, KnockoutRenin-Angiotensin SystemCalciumIon ChannelsPiezo2 protein, mouseReninblood volumecalciumion channeljuxtaglomerular granular cellkidneymechanotransductionmesangial cellPIEZO2reninrenin-angiotensin-aldosterone system

Identifiers

PMID41349545
PMCPMC12695021

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.