Evidence map›Paper›PMID 41349296›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2026

Effect of frequency on dual target deep brain stimulation.

Rocio Rodriguez Capilla, Aislinn M Hurley, Karthik Kumaravelu, Jennifer J Peters, Hui-Jie Lee, Dennis A Turner, Warren M Grill, Stephen L Schmidt

Abstract read
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In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rocio Rodriguez CapillaDepartment of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA.
Aislinn M HurleyDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Karthik KumaraveluDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Jennifer J PetersDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Hui-Jie LeeDepartment of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA.
Dennis A TurnerDepartment of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Warren M GrillDepartment of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA.
Stephen L SchmidtDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA. Electronic address: stephen.schmidt@duke.edu.

Funding

An Integrated Biomarker Approach to Personalized, Adaptive Deep Brain Stimulation in Parkinson DiseaseUH3NS129898 · NINDS · DUKE UNIVERSITY · PI DENNIS Alan TURNER · 2023 to 2026
$3.7M
Scalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous PotentialsUH3NS103468 · NINDS · DUKE UNIVERSITY · PI TURNER, DENNIS ALAN · 2017 to 2021
$2.0M
NINDS NIH HHS UH3 NS103468NINDS NIH HHS UH3 NS129898
6 · The paper itself

Abstract

backgroundDeep brain stimulation reduces the motor symptoms of Parkinson's disease (PD). Dual target deep brain stimulation (DT DBS) may better reduce symptoms and minimize side effects than single target, but the optimal parameters of DT DBS are unknown.

objectiveTo quantify the frequency response of DT DBS on bradykinesia and beta oscillations, and to explore intrahemispheric pulse delay shifts as a means to reduce total energy delivered.

methodsWe applied DT DBS using the Summit RC + S in six participants with PD, varying DBS frequency. We further examined the effects of frequency in a biophysical model.

resultsDT DBS at 50 Hz was effective at reducing bradykinesia, whereas increasing DT DBS frequency up to 125 Hz also led to significantly lower beta power. This frequency effect on beta power was replicated in a biophysical model. The model suggested that 22 Hz DT DBS, with an intrahemispheric delay of 40 ms, can reduce beta power by 87 %.

conclusionThis exploratory study (n = 6) suggests that 125 Hz DT DBS best reduced bradykinesia. However, low frequency DBS with an appropriate intrahemispheric delay could also improve symptom relief. SIGNIFICANCE: Both 125 Hz and tailored low-frequency DT DBS may achieve equivalent symptomatic control of PD symptoms.

Indexed as

Beta RhythmDeep Brain StimulationHypokinesiaParkinson DiseaseAgedFemaleHumansMaleMiddle AgedBeta OscillationsDeep Brain StimulationDual-Target Deep Brain StimulationFrequency ResponseParkinson’s Disease

Identifiers

PMID41349296
PMCPMC12695076

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.