ArticleJCO precision oncology2025
Impact of RAS-MAPK Pathway Genetic Alterations on Radiotherapy Response in Metastatic Lung Adenocarcinoma.
Article in JCO precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
Funding
Abstract
purposeTo determine whether driver gene alterations in metastatic non-small cell lung carcinoma (NSCLC) spine metastases are associated with local tumor control after radiotherapy (RT).
methodsPatients with NSCLC who underwent RT for spine metastasis and tumor genetic profiling were ascertained. Associations between driver gene mutations incidence of local failure were analyzed, followed by competing risk analysis for significant associations. The results were validated using in vitro clonal survival assays of CRISPR-engineered NSCLC cell lines.
resultsA total of 181 patients were analyzed, with a median follow-up of 15.2 months (IQR, 8.0-31.9 months). The 3-year risk of local failure was 0.15 (95% CI, 0.10 to 0.20). Patients harboring
conclusionDriver alterations in the
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