Evidence map›Paper›PMID 41348916›Full record

ArticleJBJS case connector2025

Suspected Rifampicin-Induced Fever During Periprosthetic Joint Infection Treatment: A Report of 2 Cases.

Sophie A Zwarts, Kyrill Rykov, Pelle Bos, Joris J W Ploegmakers, Wierd P Zijlstra, Marjan Wouthuyzen-Bakker

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JBJS case connector, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sophie A ZwartsDepartment of Orthopedic Surgery, Frisius Medical Centre, Leeuwarden, the Netherlands.ORCID 0009-0001-5948-704
Kyrill RykovDepartment of Orthopedic Surgery, Isala Hospital, Zwolle, the Netherlands.ORCID 0000-0002-8455-9690
Pelle BosDepartment of Orthopedic Surgery, Frisius Medical Centre, Leeuwarden, the Netherlands.ORCID 0009-0005-2144-3497
Joris J W PloegmakersDepartment of Orthopedic Surgery, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0002-1644-4015
Wierd P ZijlstraDepartment of Orthopedic Surgery, Frisius Medical Centre, Leeuwarden, the Netherlands.ORCID 0000-0001-6410-3824
Marjan Wouthuyzen-BakkerDepartment of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0001-7866-2467

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

caseDrug-induced fever is a rare adverse reaction to antibiotics. This case report describes 2 cases of suspected rifampicin-induced fever in patients undergoing periprosthetic joint infection treatment. Both patients experienced fever with the absence of inflammatory symptoms and a discrepancy between clinical improvement and persistent fever. Discontinuation of rifampicin led to rapid symptom resolution.

conclusionDrug-induced fever should be considered when fever persists without infectious symptoms and after excluding other causes. Prompt recognition and discontinuation can lead to rapid resolution and minimize unnecessary interventions.

Indexed as

Anti-Bacterial AgentsFeverProsthesis-Related InfectionsRifampinAgedFemaleHumansMaleMiddle AgedAnti-Bacterial AgentsRifampinadultadverse effectsantibiotic treatmentcomplicationDAIRelevated CRPfeverinfectionperiprosthetic join infectionPJIrifampicinS. aureuss. epidermidisTHAtotal hip arthroplasty

Identifiers

PMID41348916
PMCPMC12673901

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.