Evidence map›Paper›PMID 41348891›Full record

ArticleScience advances2025

A central CeA-LC-PVH circuit mediates stress-induced osteopenia via skeletal sympathetic nerves in male mice.

Wen-Jun Zhao, Yu-Xin Lu, Guo-Di Fan, Jie Zhou, Chao-Yang Tan, Pei-Pei Huang, Bin Ye, Fang Xie, Yu Zhu, Bang-Hui Wang and 4 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wen-Jun ZhaoInstitute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.ORCID 0009-0003-1255-4182
Yu-Xin LuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, School of Stomatology, Fourth Military Medical University, Xi'an 710032, China.ORCID 0009-0008-8079-4715
Guo-Di FanInstitute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Jie ZhouInstitute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Chao-Yang TanDepartment of Anatomy, Histology and Embryology, K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an 710032, China.ORCID 0009-0005-5333-3989
Pei-Pei HuangInstitute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Bin YeInstitute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.ORCID 0009-0007-0789-7606
Fang XieInstitute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Yu ZhuInstitute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Bang-Hui WangInstitute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Chu-Han LiuDepartment of Anatomy, Histology and Embryology, K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0003-1162-3986
Xue-Ying DouDepartment of Anatomy, Histology and Embryology, K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an 710032, China.
Yu-Lin DongDepartment of Anatomy, Histology and Embryology, K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0001-6375-7957
Xue-Yu HuInstitute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0003-0852-1196

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic stress disrupts skeletal homeostasis, yet central neural mechanisms remain unclear. In this study, we demonstrated that hyperactivation of locus coeruleus noradrenergic (LC

Indexed as

AmygdalaBone Diseases, MetabolicLocus CoeruleusParaventricular Hypothalamic NucleusStress, PsychologicalSympathetic Nervous SystemAdrenergic NeuronsAnimalsCorticotropin-Releasing HormoneDisease Models, AnimalMaleMiceCorticotropin-Releasing Hormone

Identifiers

PMID41348891
PMCPMC12680053

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.