ArticleScience advances2025
Multidimensional dynamic optical imaging unveils anesthetic-driven hemispheric lateralization in blood-brain barrier homeostasis.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Water-sensitive photoacoustic temperature characterization at 960 nm in cerebral vascular phantoms with CT co-registration.Photoacoustics · 2026Article
- Simultaneous mesoscopic imaging of neural activity and hemodynamics reveals anesthetic modulation of neurovascular responses.Photoacoustics · 2026Article
- Transcranial photoacoustic imaging of indocyanine green J-aggregates reveals cerebral signal changes in lipopolysaccharide-induced systemic inflammation.Photoacoustics · 2026Article
- A Label-Free Ultraviolet Photoacoustic Microscopy Enables Nuclear Imaging and Toxicity Assessment in an Intact Brain Organoid.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Multispectral photoacoustic microscopy and NIR-II fluorescence imaging of TREM2-positive microglia in Aβ-driven Alzheimer's pathogenesis.Fundamental research · 2026Article
- [Dual-wavelength photoacoustic microscopy for evaluation of microcirculatory dysfunction and spatial heterogeneity in mice with liver fibrosis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Unravelling theTheranostics · 2026Article
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Authors and funding
12 authors.
Funding
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Abstract
The blood-brain barrier (BBB) is commonly known to be distributed evenly within the central nervous system. This study elucidates previously unexplored physiological phenomena associated with the spatial heterogeneity of the BBB. We found that isoflurane facilitates hemispheric lateralization in BBB permeability, leading to different responses between the left and right hemispheres. To substantiate this finding, we used neural optical imaging to comprehensively map the spatial homeostasis of BBB. Image segmentation and feature extraction exhibited hemispheric lateralization in vascular microstructure and function. Gait analysis confirmed that the lateralization of BBB homeostasis influences behavioral functions. Our results indicate that the left hemisphere enhances its self-protective mechanisms by disrupting the balance of mitochondrial fission and fusion, resulting in structural changes in mitochondria and reduced ATP (adenosine 5'-triphosphate) production, which are crucial for maintaining BBB homeostasis. This study offers insights into the molecular pathways that regulate BBB integrity and their potential implications for drug delivery.
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Registered trials
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