Evidence map›Paper›PMID 41348839›Full record

ArticleACS applied materials & interfaces2025

Oral Icariin Nanoparticles Ameliorate Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress.

Shilong Fan, Ning Ma, Jiahui Li, Bingqing Wang, Yue Zhao, Yinlian Yao, Xingxing Chai, Zhikun Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shilong FanThe Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan 523808, PR China.
Ning MaChangji Vocational and Technical College, Changji 831100, PR China.
Jiahui LiThe Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan 523808, PR China.
Bingqing WangThe Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan 523808, PR China.
Yue ZhaoSchool of Pharmacy, Guangdong Medical University, Dongguan 523808, PR China.
Yinlian YaoSchool of Pharmacy, Guangdong Medical University, Dongguan 523808, PR China.
Xingxing ChaiSchool of Pharmacy, Guangdong Medical University, Dongguan 523808, PR China.
Zhikun ZhouThe Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan 523808, PR China.ORCID 0000-0001-9697-5897

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammatory liver conditions, such as nonalcoholic fatty liver disease (NAFLD), are frequently exacerbated by oxidative stress, rendering the neutralization of reactive oxygen species (ROS) crucial for their amelioration. Oral administration of nanoparticles (NPs) presents an optimal strategy for NAFLD management due to its convenience. This research aimed to overcome the poor water solubility and low bioavailability of icariin (ICA) by engineering an oral nanosystem, ICA-loaded poly(lactic-

Indexed as

AntioxidantsFlavonoidsNanoparticlesNon-alcoholic Fatty Liver DiseaseOxidative StressAdministration, OralAnimalsChitosanDiet, High-FatHep G2 CellsHumansLiverMaleMiceMice, Inbred C57BLPolylactic Acid-Polyglycolic Acid CopolymerAntioxidantsChitosanFlavonoidsicariinPolylactic Acid-Polyglycolic Acid CopolymerReactive Oxygen Speciesicariinliver targetedNAFLDoral delivery nanoparticleROS

Identifiers

PMID41348839
PMCPMC12723645

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.