Evidence map›Paper›PMID 41348733›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis.

Jun Xia, Lingxue Shen, Yining Liu, Lu Wang, Feng Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jun Xia *Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266237, China.ORCID 0009-0005-3996-2551
Lingxue Shen *Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266237, China.
Yining Liu *State Key Laboratory of Organ Regeneration and Reconstruction Beijing Institute for Stem Cell and Regenerative Medicine, Institute of Zoology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China.
Lu WangState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.ORCID 0000-0003-4788-3237
Feng LiuShandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266237, China.ORCID 0000-0003-3228-0943

Funding

MOST | National Natural Science Foundation of China (NSFC) (32030032
6 · The paper itself

Abstract

During vertebrate embryogenesis, hematopoietic stem and progenitor cells (HSPCs) originate from hemogenic endothelium (HE) in the dorsal aorta through endothelial-to-hematopoietic transition (EHT). While basal inflammation is essential for this process, excessive immune activation disrupts HSPC emergence. Here, we identify angiotensin-converting enzyme 2 (Ace2), a key component of renin-angiotensin system, as a crucial anti-inflammatory regulator of embryonic hematopoiesis in zebrafish and mice. Loss of Ace2 impairs HE specification and reduces nascent HSPC production. Mechanistically, transcriptomic profiling reveals that

Indexed as

Hematopoietic Stem CellsNLR Family, Pyrin Domain-Containing 3 ProteinPeptidyl-Dipeptidase APyroptosisZebrafish ProteinsAngiotensin-Converting Enzyme 2Angiotensin IAnimalsHematopoiesisMicePeptide FragmentsSignal TransductionZebrafishAce2 protein, mouseAngiotensin-Converting Enzyme 2Angiotensin Iangiotensin I (1-7)NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePeptide FragmentsPeptidyl-Dipeptidase AZebrafish ProteinsAce2hematopoietic stem and progenitor cellsNlrp3 signalingpyroptosiszebrafish

Identifiers

PMID41348733
PMCPMC12704739

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.