Evidence map›Paper›PMID 41348706›Full record

ReviewPediatric neurosurgery2026

Single-Neuron Recordings Research in Children: Ethical Considerations, Feasibility, Technical Aspects, and Scientific Opportunities.

David Bonda, Clayton P Mosher, Naga Sai Anagha Devulapalli, Ishan Kanungo, Edwina Tran, Stuart G Finder, Ueli Rutishauser, Adam Mamelak

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David BondaDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA, david.bonda@cshs.org.
Clayton P MosherDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Naga Sai Anagha DevulapalliDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Ishan KanungoDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Edwina TranDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Stuart G FinderCenter for Healthcare Ethics, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Ueli RutishauserDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Adam MamelakDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Funding

Neuronal mechanisms of human episodic memoryU01NS117839 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI MAMELAK, ADAM NATHANIEL, RUTISHAUSER, UELI · 2020 to 2024
$7.8M
NINDS NIH HHS U01 NS117839
6 · The paper itself

Abstract

backgroundHuman intracranial recordings and single-neuron recordings in particular have provided much knowledge on the mechanisms of human cognition and its impairment by disease. Improvements in recording technology, experimental design, and computational analysis methods have permitted an increasingly sophisticated understanding of uniquely human brain processes, including those underlying executive function, memory, and language. Despite the routine clinical use of intracranial recordings for invasive epilepsy monitoring in the pediatric population, there remains a significant gap between the associated research conducted in adult and pediatric neuroscientific investigation. SUMMARY: Single-neuron recordings in pediatric epilepsy patients are ethical, technically feasible, and safe. These data can provide mechanistic insights into the neurophysiology of the developing human brain. KEY MESSAGES: Routine use of invasive electrophysiological monitoring via stereoelectroencephalography studies in pediatric drug-resistant epilepsy offers opportunities to extend the utility of single-neuron recordings to the pediatric population and advance our knowledge of the neuronal basis of behaviors in children.

Indexed as

Biomedical ResearchBrainDrug Resistant EpilepsyNeuronsChildFeasibility StudiesHumansCognitive controlHuman single neuronsIntracranial recordingsNeuroethicsPediatrics

Identifiers

PMID41348706
PMCPMC12709666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.