Evidence map›Paper›PMID 41348648›Full record

ArticleJournal of neurophysiology2026

A respiratory signature of disease progression in the Pompe rat.

Alyssa R Mickle, Sabhya Rana, Ethan S Benevides, Barry J Byrne, David D Fuller, Erica A Dale

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alyssa R MickleDepartment of Neuroscience, University of Florida, Gainesville, Florida, United States.
Sabhya RanaBreathing Research and Therapeutics Center, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-1303-6614
Ethan S BenevidesBreathing Research and Therapeutics Center, University of Florida, Gainesville, Florida, United States.
Barry J ByrneBreathing Research and Therapeutics Center, University of Florida, Gainesville, Florida, United States.
David D FullerBreathing Research and Therapeutics Center, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-5013-5972
Erica A DaleDepartment of Neuroscience, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-9909-8858

Funding

Control of Breathing & Glycogen Storage DiseaseR01HD052682 · NICHD · UNIVERSITY OF FLORIDA · PI BYRNE, BARRY J, FULLER, DAVID D · 2007 to 2024
$6.4M
Breathing Research and Therapeutics (BREATHE)T32HL134621 · NHLBI · UNIVERSITY OF FLORIDA · PI Gordon S. Mitchell · 2017 to 2026
$3.4M
Cervical Epidural Stimulation and Respiratory Motor PlasticityR01HL153102 · NHLBI · UNIVERSITY OF FLORIDA · PI DALE, ERICA ARDEN · 2021 to 2025
$2.0M
Closed-loop epidural stimulation: respiratory motor plasticity and neural underpinningsF31HL174079 · NHLBI · UNIVERSITY OF FLORIDA · PI MICKLE, ALYSSA RICHELLE · 2025 to 2025
$34k
HHS | National Institutes of Health (NIH) 1F31HL174079-01A1HHS | National Institutes of Health (NIH) 2R01HD052682-11a1HHS | National Institutes of Health (NIH) R01HL153102HHS | National Institutes of Health (NIH) T32HL134621NHLBI NIH HHS F31 HL174079NHLBI NIH HHS R01 HL153102NHLBI NIH HHS T32 HL134621NICHD NIH HHS R01 HD052682
6 · The paper itself

Abstract

Early-onset Pompe disease occurs due to mutations in the acid α-glucosidase (GAA) gene that result in the absence of functional GAA protein. This results in widespread glycogen accumulation and cardiorespiratory failure early in life. We used a Gaa null (

Indexed as

DiaphragmGlycogen Storage Disease Type IIRespirationalpha-GlucosidasesAnimalsDisease Models, AnimalDisease ProgressionElectromyographyMalePlethysmographyPlethysmography, Whole BodyRatsRats, Sprague-Dawleyalpha-GlucosidaseselectromyographyplethysmographyPompe diseaserespiration

Identifiers

PMID41348648
PMCPMC12873631

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.