Evidence map›Paper›PMID 41348644›Full record

ReviewBlood advances2026

The interplay of von Willebrand disease and women's reproductive health.

Arielle L Langer, Sarah H O'Brien

Abstract readReview
In one paragraph

Review in Blood advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Von Willebrand disease: A century of progress.Research and practice in thrombosis and haemostasis · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Arielle L LangerDivision of Hematology, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-0301-7073
Sarah H O'BrienDivision of Pediatric Hematology and Oncology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH.ORCID 0000-0001-8855-9746

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractVon Willebrand disease (VWD) is the most common inherited bleeding disorder and is often diagnosed in the setting of heavy menstrual bleeding. Because estrogen upregulates von Willebrand factor synthesis, pregnancy and management of menses may influence VWD testing and diagnosis. Throughout the life span, the management of women's reproductive health is frequently affected by VWD. We seek to describe the interplay between VWD and women's reproductive health at 3 distinct phases in life: menarche and menstruation, maternal health and fertility, and menopause and aging. Planning for care requires screening for VWD in the setting of reproductive bleeding, counseling patients about expectations, and monitoring for iron deficiency across all 3 phases. Hemostatic plans should be tailored to both factor levels and patient preference. Emphasis is placed on areas lacking vital data.

Indexed as

Reproductive Healthvon Willebrand DiseasesWomen's HealthFemaleHumansMenarcheMenopausePregnancy

Identifiers

PMID41348644
PMCPMC13045578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.