Observational studyClinical journal of the American Society of Nephrology : CJASN2026
Outcomes of Deceased Donor Kidney Transplants Allocated Out of Sequence in the United States.
Observational study in Clinical journal of the American Society of Nephrology : CJASN, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Is the Current Practice of Out-of-Sequence Kidney Allocation Justified? Assessing Outcomes, Utility, Efficiency, and Equity.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
key pointsWe used national data to examine the outcomes of kidney transplant allocated as out of sequence offers to transplant centers in the United States. Short-term kidney graft failure does not differ between kidneys that were allocated as out of sequence offers versus standard allocation.
backgroundChanges in kidney allocation policies and regulations of Organ Procurement Organizations have affected the volume of organ offers and challenged transplant providers. One consequence is increased kidneys allocated out of sequence (OOS).
methodsRetrospective observational study using Scientific Registry of Transplant Recipient data from 2021 to 2023, we analyzed donor and recipient characteristics for OOS versus standard kidney allocation and multivariable Cox models to evaluate graft survival. We also compared paired donors (one kidney OOS and the other standard allocation).
resultsAnnual OOS kidney allocation rates increased from 5.4% in 2021 to 18.4% in 2023. High OOS-use centers increased from 5 (2.2%) between 2021 and June 2022 to 37 (17%) in 2023. Listing at a high-OOS usage center was associated with increased rate of deceased donor transplantation (adjusted hazard ratio [AHR], 3.07; 95% confidence interval [CI], 2.90 to 3.25). Recipients of OOS allocation were more likely to be male (66% versus 59%), White race (38% versus 32%), privately insured (29% versus 24%), and preemptively transplanted (18% versus 10%). Overall graft loss was not significantly different between OOS and standard allocated transplants (AHR, 0.94; 95% CI, 0.85 to 1.05), consistent in paired donor analysis (AHR, 1.10; 95% CI, 0.86 to 1.41).
conclusionsShort-term kidney graft failure does not differ between OOS and standard allocation. High-OOS kidney centers have higher deceased donor transplant rates. Further investigation is needed to understand demographic differences and factors explaining OOS allocation.
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