Evidence map›Paper›PMID 41348443›Full record

ArticleMicrobial genomics2025

Cervicovaginal microbiome composition and absolute quantity are associated with pelvic inflammatory disease.

Laurence Don Wai Luu, Ciara Bryant, James Brown, Mark Turner, Thi Huong Pham, Rami Mazraani, Catherine Burke, Brittany Jury, Manisha Shrestha, Kirsty Fleming and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Laurence Don Wai LuuSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
Ciara BryantSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
James BrownSchool of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
Mark TurnerSchool of Agriculture and Food Sustainability, Faculty of Science, The University of Queensland, St Lucia, QLD, Australia.
Thi Huong PhamSchool of Agriculture and Food Sustainability, Faculty of Science, The University of Queensland, St Lucia, QLD, Australia.
Rami MazraaniSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
Catherine BurkeSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
Brittany JurySchool of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
Manisha ShresthaSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.
Kirsty FlemingFamily Planning Australia, Newington, NSW, Australia.
Deborah BatesonThe Daffodil Centre, A Joint Venture between Cancer Council NSW and the University of Sydney, Sydney, Australia.
Darren RussellCairns Sexual Health Service, QLD Health, Cairns North, QLD, Australia.
Faith BassettCairns Sexual Health Service, QLD Health, Cairns North, QLD, Australia.
Evonne OngFamily Planning Australia, Newington, NSW, Australia.
Jane S HockingMelbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.
Sally SweeneyFamily Planning Australia, Newington, NSW, Australia.
Wilhelmina May HustonSchool of BioSciences, Faculty of Science, University of Melbourne, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pelvic inflammatory disease (PID), which involves infection and inflammation of the female reproductive tract, can lead to sequelae including chronic pelvic pain, ectopic pregnancy and tubal factor infertility. A causative pathogen is not identified in many PID cases (idiopathic PID) and does not develop in all women with a sexually transmitted infection or bacterial vaginosis. Therefore, there is a need to better understand the pathogenesis of PID. A case-control study was conducted to explore microbiome, antibiotic resistance and immune gene expression in PID. Microbial profiling using both 16S rRNA gene amplicon and metagenomic approaches revealed that bacterial vaginosis-associated bacteria such as

Indexed as

BacteriaCervix UteriMicrobiotaPelvic Inflammatory DiseaseVaginaAdultCase-Control StudiesFemaleGardnerella vaginalisHumansMetagenomicsRNA, Ribosomal, 16SVaginosis, BacterialYoung AdultRNA, Ribosomal, 16Santibioticcervical microbiomedysbiosisLactobacillusreproductive infectionsexually transmitted infectionvaginal microbiome

Identifiers

PMID41348443
PMCPMC12680322

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.