SynthesisEuropean geriatric medicine2026
Multimorbidity patterns and mental health in late life: a systematic review of longitudinal studies.
Synthesis in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multimorbidity and the risk of depression: a systematic review of cohort studies.Journal of global health · 2026Pooled it
- Article
- Multimorbidity patterns and cognitive trajectories in older adults: functional, behavioral, and environmental pathways-a longitudinal analysis of CHARLS.Research square · 2026Article
- Functional Limitation and Favorable Mental-Health Self-Appraisal Among U.S. Adults Aged 50 Years or Older with Multimorbidity: A Behavioral-Science Analysis of the 2023 Medical Expenditure Panel Survey.Behavioral sciences (Basel, Switzerland) · 2026Article
- Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study.Acta neuropsychiatrica · 2026Review
- Chronic disease multimorbidity and mental health among older adults in China: The moderating roles of family and social support.PloS one · 2026Article
- Association between 24-h movement behaviors and psychological distress in older adults with chronic diseases: a compositional isotemporal substitution analysis.Frontiers in psychology · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSeveral chronic disease combinations (i.e., multimorbidity [MM] patterns) have been linked to poor mental health. This systematic review aimed to synthesize evidence on the longitudinal association between MM patterns and several mental health conditions in later life, including depression, anxiety, suicidality, cognitive decline, and dementia.
methodsFollowing PRISMA guidelines (PROSPERO: CRD42024537617), we included longitudinal studies of middle-to-older individuals (45 +) that examined baseline MM patterns and the incidence or trajectories of depression, anxiety, dementia, cognitive decline, or suicidality. The search was conducted in MEDLINE and Web of Science from inception to March 2024, and involved independent screening and quality assessment using a modified Newcastle-Ottawa Scale.
resultsFrom 13,771 retrieved records, 17 studies were included, ranging from 1209 to 447,888 participants. Fourteen studies were population-based, with follow-ups between 2 and 16 years. Most studies investigated depression (n = 7) and dementia/cognitive decline (n = 9). MM pattern definitions varied, most often relying on data-driven methods (e.g., latent class analysis) and encompassing different numbers and types of diseases. Methodological quality was high across studies. MM patterns featuring cardiometabolic diseases were associated with higher risk of depression, anxiety, cognitive decline, and dementia. Patterns characterized by musculoskeletal, gastrointestinal, and pain-related conditions also showed associations with depression and anxiety. Two studies examined suicidality, with greater multimorbidity burden linked to increased suicidal ideation.
conclusionMM patterns linked to higher clinical complexity present poorer mental health trajectories. Validation of MM patterns within and across populations is key for identifying older adults with complex health profiles who may benefit from targeted care strategies.
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