Evidence map›Paper›PMID 41348383›Full record

ReviewMolecular and cellular biochemistry2026

The role of amino acid signaling in pathogenesis of chronic kidney disease.

Siya Yan, Xiangqi Zhang, Ruizhen Bu, Ge Li, Yang Wang, Meifang Cheng, Qian Chen, Yuzheng Wu, Yi Zhang, Dan Wang and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Siya YanState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Xiangqi ZhangTianjin Darentang Jingwanhong Pharmaceutical Co., Ltd, 20 Daming Road, Xiqing Dist., Tianjin, 300112, China.
Ruizhen BuTianjin Darentang Jingwanhong Pharmaceutical Co., Ltd, 20 Daming Road, Xiqing Dist., Tianjin, 300112, China.
Ge LiNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Yang WangState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Meifang ChengNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Qian ChenState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Yuzheng WuState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Yi ZhangNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Dan WangState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. nkwangdan0048@tjutcm.edu.cn.
Tao WangHaihe Laboratory of Modern Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. wangtao@tjutcm.edu.cn.

Funding

College Students' Innovation and Entrepreneurship Training Program Project 202510063002National Natural Science Foundation of China 82304870Tianjin University of Traditional Chinese Medicine Graduate Student Research Innovation Project YJSKC-20240031
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is a comprehensive disease characterized by renal injury and decreased renal function, which can lead to increased cardiovascular and all cause mortality rates, seriously affecting the quality of life and lifespan of patients. At present, although renal function decline can be treated with hormone drugs and immunosuppressive drugs, these treatment methods have not shown any beneficial effects on preventing CKD from progressing to renal failure. Dietary intervention has always been one of the cornerstones of CKD treatment, and nephrologists use dietary intervention to reduce symptoms and metabolic complications of CKD and potentially prevent its progression. This review discusses the relationship between kidney disease and amino acids. In addition, we emphasize the regulatory role of amino acid signaling pathways in the progression of CKD, with a focus on causal relationships and potential mechanisms.

Indexed as

Amino AcidsRenal Insufficiency, ChronicSignal TransductionAnimalsHumansAmino AcidsAmino acid sensingChronic kidney diseaseGeneral control nonderepressible 2 kinaseMammalian target of rapamycinSignaling pathway

Identifiers

PMID41348383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.