Evidence map›Paper›PMID 41348375›Full record

ArticleSleep & breathing = Schlaf & Atmung2025

SAS-CARE-1 study: stroke topography and polysomnography-based respiratory sleep characteristics.

Irina Filchenko, Anne-Kathrin Brill, Martijn P J Dekkers, Sébastien Baillieul, Andrea Seiler, Mauro Manconi, Roland Wiest, Corrado Bernasconi, Markus H Schmidt, Claudio L A Bassetti

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Irina FilchenkoDepartment of Neurology, Bern University Hospital (Inselspital), University of Bern, Freiburgstrasse 16, Bern, 3010, Switzerland. Irina.Filchenko@insel.ch.ORCID http://orcid.org/0000-0002-9486-1017
Anne-Kathrin BrillDepartment of Pulmonary Medicine and Allergology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 16, Bern, 3010, Switzerland.
Martijn P J DekkersDepartment of Neurology, Bern University Hospital (Inselspital), University of Bern, Freiburgstrasse 16, Bern, 3010, Switzerland.
Sébastien BaillieulDepartment of Neurology, Bern University Hospital (Inselspital), University of Bern, Freiburgstrasse 16, Bern, 3010, Switzerland.
Andrea SeilerDepartment of Neurology, Bern University Hospital (Inselspital), University of Bern, Freiburgstrasse 16, Bern, 3010, Switzerland.
Mauro ManconiDepartment of Neurology, Bern University Hospital (Inselspital), University of Bern, Freiburgstrasse 16, Bern, 3010, Switzerland.
Roland WiestDepartment of Neuroradiology, University Hospital, Inselspita, Bern, Switzerland.
Corrado BernasconiDepartment of Neurology, Bern University Hospital (Inselspital), University of Bern, Freiburgstrasse 16, Bern, 3010, Switzerland.
Markus H Schmidt *Department of Neurology, Bern University Hospital (Inselspital), University of Bern, Freiburgstrasse 16, Bern, 3010, Switzerland.
Claudio L A Bassetti *Department of Neurology, Bern University Hospital (Inselspital), University of Bern, Freiburgstrasse 16, Bern, 3010, Switzerland. Claudio.Bassetti@unibe.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSleep-disordered breathing (SDB) is a risk factor of ischemic stroke but can also appear "de novo" after the acute brain damage. The link between SDB and stroke topography, which remains controversial, was assessed in this study.

methodsThis is a post-hoc analysis of the multicenter prospective SAS-CARE-1 study, which included 259 patients with acute stroke or transient ischemic attack. Assessments comprised demographics, medical history, and brain magnetic resonance imaging (MRI) at admission. In 101 patients with acute stroke, MRI-based stroke topography was binary coded for the involvement as supra- (cortical and/or subcortical) and/or infratentorial (brainstem and/or cerebellar) locations. Polysomnography was performed at admission (n = 101) and at 3 months post-stroke (n = 72).

resultsA linear regression with adjustments for age and sex identified an association of brainstem stroke with a higher obstructive apnea index (OAI; 9.91 events/h for brainstem stroke versus no brainstem involvement, p = 0.003) at acute stroke, but not at 3 months post-stroke. Correspondingly, the decrease of OAI from acute to 3 months post-stroke was associated with brainstem (-10.72 events/h, p = 0.011) stroke with adjustment for age and sex. However, this association was not significant with an additional adjustment for baseline OAI. There were no other significant associations.

conclusionThis study confirms the previously reported association between brainstem stroke and obstructive apneas. Further research is needed to elucidate the link between focal brain damage and respiratory control during sleep.

Indexed as

Ischemic Attack, TransientPolysomnographySleep Apnea, ObstructiveSleep Apnea SyndromesStrokeAgedBrain StemFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRisk FactorsCentral sleep apnea indexIschemic strokeObstructive apnea indexPolysomnographySleep-disordered breathing

Identifiers

PMID41348375
PMCPMC12680655

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.