Evidence map›Paper›PMID 41348317›Full record

ArticleSurgery today2026

Pancreatic extracellular volume fraction on multiphasic contrast-enhanced computed tomography for predicting pancreatic fistula after pancreatoduodenectomy.

Hayato Abe, Yukiyasu Okamura, Nao Yoshida, Yusuke Mitsuka, Osamu Aramaki, Kenichiro Tago, Masahiro Okada, Noriyuki Nakano, Shinobu Masuda, Seiichi Udagawa

Abstract read
PubMed Publisher
In one paragraph

Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hayato AbeDivision of Digestive Surgery, Department of Surgery, Nihon University School of Medicine, 30-1, Oyaguchikami-machi, Itabashi-ku, Tokyo, 173-8610, Japan.
Yukiyasu OkamuraDivision of Digestive Surgery, Department of Surgery, Nihon University School of Medicine, 30-1, Oyaguchikami-machi, Itabashi-ku, Tokyo, 173-8610, Japan. okamura.yukiyasu@nihon-u.ac.jp.
Nao YoshidaDivision of Digestive Surgery, Department of Surgery, Nihon University School of Medicine, 30-1, Oyaguchikami-machi, Itabashi-ku, Tokyo, 173-8610, Japan.
Yusuke MitsukaDivision of Digestive Surgery, Department of Surgery, Nihon University School of Medicine, 30-1, Oyaguchikami-machi, Itabashi-ku, Tokyo, 173-8610, Japan.
Osamu AramakiDivision of Digestive Surgery, Department of Surgery, Nihon University School of Medicine, 30-1, Oyaguchikami-machi, Itabashi-ku, Tokyo, 173-8610, Japan.
Kenichiro TagoDivision of Radiology, Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
Masahiro OkadaDivision of Radiology, Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
Noriyuki NakanoDivision of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
Shinobu MasudaDivision of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
Seiichi UdagawaDivision of Natural Sciences, Department of Liberal Education, Nihon University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to assess whether the pancreatic extracellular volume (ECV) fraction on multiphasic contrast-enhanced computed tomography (CE-CT) can estimate histological pancreatic fibrosis and predict clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreatoduodenectomy (PD).

methodsThis single-center retrospective study included 106 patients who underwent multiphasic CE-CT and PD. ECV fractions were calculated based on absolute enhancements of the pancreas and aorta between the pre-contrast and equilibrium-phase images, followed by a comparison between different fibrosis grades. Multivariate logistic regression analyses were used to evaluate the association between the risk of CR-POPF development and perioperative factors.

resultsOf 106 patients, 45 (42.5%) developed POPF (biochemical leak, n = 8; grades B and C, n = 37). The ECV fraction (median, 40.1%; range, 20.0–87.7%) showed a moderate positive correlation with pancreatic fibrosis grade (r = 0.549, P < 0.001). In the multivariate analysis, the ECV fraction (< 40%; odds ratio, 10.1; 95% confidence interval, 3.32–36.3; P < 0.001) was identified as the only independent risk factor for CR-POPF. The area under the receiver operating characteristic curve was 0.824 for the correlation between ECV fraction and CR-POPF prediction, with a cutoff value of 40.9%.

conclusionThe pancreatic ECV fraction provides quantitative information for assessing pancreatic fibrosis and predicting CR-POPF after PD.

Indexed as

PancreasPancreatic FistulaPancreaticoduodenectomyPostoperative ComplicationsTomography, X-Ray ComputedAgedAged, 80 and overContrast MediaFemaleFibrosisHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesContrast MediaExtracellular volume fractionPancreatic fibrosisPancreatoduodenectomyPostoperative pancreatic fistula

Identifiers

PMID41348317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.