ArticleGeroScience2026
The immuno-neurological axis: association between autoimmune diseases and dementia risk.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dementia is a growing global public health concern, with an increasing number of individuals affected due to the aging population. Although chronic inflammation is implicated in cognitive impairment, studies on its association with autoimmune diseases, which are representative chronic inflammatory diseases, are lacking. This study aimed to investigate whether the onset of autoimmune diseases is associated with an increased risk of dementia or cognitive impairment. This study used data from the Korean National Health Insurance Service-Health Screening from 2002 to 2019, with 8,743,801 person-years. The risk of dementia according to the type of autoimmune disease was calculated using the Cox proportional hazards model. The status and risk of cognitive impairment, which were assessed using the Korean Dementia Screening Questionnaire-Prescreening related with autoimmune diseases also estimated. Among participants, 8.3% developed dementia. All autoimmune diseases significantly increased dementia risk (hazard ratio [HR] 1.32; 95% confidence interval [CI] 1.29-1.35), particularly Alzheimer's disease (HR 1.36; 95% CI, 1.32-1.40), vascular dementia (HR, 1.21; 95% CI, 1.12-1.30), and unspecified dementia (HR, 1.25; 95% CI, 1.18-1.33). Autoimmune diseases also increased the risk of positive dementia screening (odds ratio [OR], 1.18; 95% CI, 1.12-1.24), particularly connective tissue disorders (OR, 1.24; 95% CI, 1.15-1.34). This large-scale cohort study demonstrates a significant association between autoimmune diseases and increased risk of dementia and cognitive impairment. These findings underscore the potential importance of chronic inflammation in dementia pathogenesis and highlight the need for early cognitive screening and intervention strategies in patients with autoimmune diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.