ArticleDiscover oncology2025
Lidocaine suppresses HER2-positive breast cancer cell proliferation by targeting the OGT-CCNL1 axis.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The effect of lidocaine in breast cancer: a concise overview of preclinical and clinical evidence.Frontiers in pharmacology · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
backgroundHER2-positive breast cancer, known for its heterogeneity and complex molecular mechanisms, poses a significant therapeutic challenge. Lidocaine, a widely used local anesthetic, has recently been identified as a potential anticancer agent. This study investigates the effects of lidocaine on HER2-positive breast cancer proliferation and the underlying mechanisms.
methodsThe effects of lidocaine on cell proliferation, cell cycle distribution, and O-GlcNAcylation levels in AU565 and BT474 cells were assessed using CCK-8 assays, EdU incorporation assays, flow cytometry, and western blot analysis. Furthermore, the interaction between lidocaine and OGT was examined using molecular docking and co-immunoprecipitation (co-IP) experiments.
resultsLidocaine was found to significantly inhibit cell viability and proliferation in AU565 and BT474 cells, inducing G0/G1 cell cycle arrest. Mechanistically, lidocaine was observed to downregulate O-GlcNAc transferase (OGT), consequently reducing global O-GlcNAcylation levels. We further demonstrated that OGT interacts with and stabilizes CCNL1 via O-GlcNAcylation, and this interaction is critical for CCNL1-mediated cancer cell proliferation. Notably, rescue experiments revealed that the overexpression of either OGT or CCNL1 could partially reverse the suppressive effects of lidocaine.
conclusionsIn conclusion, this study reveals a novel mechanism by which lidocaine inhibits HER2-positive breast cancer cell proliferation by targeting the OGT-CCNL1 axis, highlighting a potential therapeutic avenue for HER2-positive breast cancer.
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