Evidence map›Paper›PMID 41348259›Full record

ArticleJournal of assisted reproduction and genetics2026

Reduced oxygen tension during embryo culture and neonatal growth outcomes: a large retrospective cohort study of 13,831 fresh IVF/ICSI singleton births.

Li Lei, Ming Li, Qingqing Tao, Jin Huang, Qin Li, Ying Lian, Jie Qiao, Rong Li, Ping Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li Lei *State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Ming Li *State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. bysylm@hsc.pku.edu.cn.ORCID http://orcid.org/0000-0001-8415-7010
Qingqing TaoState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Jin HuangState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Qin LiState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Ying LianState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Jie QiaoState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Rong LiState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Ping LiuState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. bysylp@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate whether reduced oxygen tension (5% O

methodsWe conducted a retrospective cohort study at Peking University Third Hospital (2015-2022), including 13,831 singleton live births after fresh cleavage-stage transfers. Neonates conceived under 5% O

resultsCompared with 20% O

conclusionsReduced oxygen tension during embryo culture was associated with lower neonatal birthweight and a reduced incidence of LGA or macrosomic infants, indicating a favorable effect on neonatal outcomes. Prospective multicenter and mechanistic studies are warranted to confirm these findings and refine oxygen management in Assisted reproductive technologies (ART).

Indexed as

Embryo Culture TechniquesFertilization in VitroOxygenSperm Injections, IntracytoplasmicAdultBirth WeightEmbryo TransferFemaleGestational AgeHumansInfant, NewbornInfant, Small for Gestational AgeLive BirthMalePregnancyPregnancy OutcomeOxygenBirth weightEmbryo cultureMacrosomiaNeonatal outcomesOxygen tension

Identifiers

PMID41348259
PMCPMC12900988

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.