Evidence map›Paper›PMID 41348254›Full record

ReviewCurrent pain and headache reports2025

Capsaicin in the Management of Peripheral Neuropathy: A Review.

Rabiul Ryan, Ramzan Judge, Jesse Lou, Andrew Ng

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rabiul RyanDepartment of Anesthesiology, Jefferson Pain Center, Sidney Kimmel Medical College, Thomas Jefferson University, 3 Crescent Drive, Philadelphia, PA, 19112, USA.
Ramzan JudgeDeborah Heart and Lung Center, Browns Mills, NJ, USA.
Jesse LouDepartment of Anesthesiology, Jefferson Pain Center, Sidney Kimmel Medical College, Thomas Jefferson University, 3 Crescent Drive, Philadelphia, PA, 19112, USA.
Andrew NgDepartment of Anesthesiology, Jefferson Pain Center, Sidney Kimmel Medical College, Thomas Jefferson University, 3 Crescent Drive, Philadelphia, PA, 19112, USA. Andrew.Ng@jefferson.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe purpose of this review is to provide an update on the efficacy and safety of capsaicin in the treatment of neuropathic pain. RECENT

findingsCapsaicin can provide prolonged relief from pain in various neuropathies. One proposed mechanism is the ability to cause degeneration of hypersensitized nerve tissue and incite regeneration of healthy nerve fibers. Capsaicin provides more significant relief than placebo and is non-inferior to pregabalin in the treatment of peripheral neuropathy. It is emerging as an alternative but effective and well-tolerated treatment for neuropathy due to diverse pathologic conditions. Capsaicin, a natural agonist at the TRPV1 receptor, has been studied for its therapeutic role in neuropathic pain. Capsaicin is an effective treatment with significant reduction in both diabetic and non-diabetic neuropathic pain. Due to its topical application, it is associated with fewer systemic adverse events and therefore, an attractive option in the treatment of peripheral neuropathy.

Indexed as

CapsaicinNeuralgiaPeripheral Nervous System DiseasesSensory System AgentsDiabetic NeuropathiesHumansCapsaicinSensory System AgentsCapsaicinDiabetic neuropathyPeripheral neuropathy

Identifiers

PMID41348254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.