Evidence map›Paper›PMID 41348231›Full record

ReviewArchives of virology2025

Adaptive immune response of poultry to Newcastle disease vaccines.

Yuhao Chai, Zenglei Hu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yuhao ChaiJoint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, China.
Zenglei HuJoint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, China. zengleihu@163.com.ORCID http://orcid.org/0000-0002-8102-595X

Funding

National Natural Science Foundation 32372977
6 · The paper itself

Abstract

Newcastle disease (ND), caused by virulent Newcastle disease virus (NDV), poses a major global threat to the poultry industry. ND vaccines have been used for nearly 70 years for disease prevention and control, and much is known about adaptive immune responses to infection and vaccination. However, our current knowledge remains incomplete and biased. While humoral immunity, especially regarding the induction of hemagglutination-inhibiting and virus-neutralizing antibodies, has been studied extensively, research on mucosal and cellular immunity has been more limited, despite their critical roles in restricting and clearing viral infection. Furthermore, fundamental questions persist even for humoral responses, such as the role of antibodies against viral internal proteins, the mechanisms of virus neutralization by antibodies, and the effect of antibody production on viral evolution. This review systematically summarizes existing knowledge on adaptive immunity to NDV infection, encompassing humoral, mucosal, and cellular aspects. It also highlights key gaps in our understanding of immune responses in poultry, which is important for developing novel vaccines and control strategies.

Indexed as

Adaptive ImmunityNewcastle DiseaseNewcastle disease virusPoultry DiseasesViral VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralChickensImmunity, CellularImmunity, HumoralPoultryVaccinationAntibodies, NeutralizingAntibodies, ViralViral Vaccines

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.