Evidence map›Paper›PMID 41348205›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026

10-Year trend of lateral lumbar interbody fusion and the impact of 3D-printed titanium in a high-volume academic center.

Marco D Burkhard, Ali E Guven, Anna-Maria Mielke, Paul Köhli, Jan Hambrecht, Torben Stepan, Bruno Verna, Erika Chiapparelli, Jennifer Shue, Federico P Girardi and 3 more

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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marco D BurkhardDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA. burkhardm@hss.edu.
Ali E GuvenDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.
Anna-Maria MielkeDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.
Paul KöhliDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.
Jan HambrechtDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.
Torben StepanDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.
Bruno VernaDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.
Erika ChiapparelliDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.
Jennifer ShueDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.
Federico P GirardiDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.
Frank P CammisaDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.
Andrew A SamaDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.
Alexander P HughesDepartment of Orthopaedic Surgery, Hospital for Special Surgery, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study is to evaluate utilization trends of standalone (SA) lateral lumbar interbody fusion (LLIF) and circumferential (360) LLIF after the transition from polyetheretherketone (PEEK) to 3D-printed titanium (3DTi) at a high-volume academic center.

methodsWe retrospectively reviewed all LLIF procedures performed at a single center from 2014 to 2023, assessing trends in SA-LLIF utilization and cage material choice (PEEK vs. 3DTi). A regression analysis with an interaction term assessed changes in SA-LLIF trends following 3DTi implementation (2017/2018). SA-LLIF rates were compared between 3DTi adopters and a surgeon who continued using PEEK in pre- (2014-2017) and post-transition (2019-2023) periods using chi-square tests.

resultsA total of 1836 patients (3,257 levels) were included, with 41.6% (764 patients; 1332 levels) undergoing SA-LLIF. Three surgeons adopted 3DTi cages in 2017-2018, while one continued using PEEK. During the post-3DTi-transition period, SA-LLIF utilization showed an annual increase of 11% (p = 0.007), while a non-significant downward trend was noted for the surgeon who continued using PEEK. Among 3DTi adopters, SA-LLIF utilization was higher in the post-transition period (44.8% in 2019-2023 vs. 28.3% in 2014-2018, p < 0.001), with no significant change for the surgeon who continued using PEEK. This upward trend was also observed in patients with osteoporosis, obesity, degenerative scoliosis, and prior laminectomy (all p < 0.05).

conclusionSA-LLIF utilization was significantly higher in the period after 3DTi adoption. These patterns are consistent with the hypothesis that the biomechanical properties of 3DTi cages could support broader use of SA-LLIF in a wider patient population, although causality cannot be established from this study.

Indexed as

Lumbar VertebraePrinting, Three-DimensionalSpinal FusionTitaniumAgedBenzophenonesFemaleHumansKetonesMaleMiddle AgedPolyethylene GlycolsPolymersRetrospective StudiesBenzophenonesKetonespolyetheretherketonePolyethylene GlycolsPolymersTitanium3D-PrintLateral lumbar interbody fusionPEEKSpine fusionTitanium

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.