ArticleJACC. Case reports2026
Statin-Induced Decade-Long Stabilization of Noncalcified Coronary Plaque Despite a Zero Calcium Score.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundA 48-year-old man with a coronary artery calcium (CAC) score of 0 underwent serial artificial intelligence (AI)-assisted coronary computed tomography angiography (CCTA) from 2015 to 2026, which revealed progressive noncalcified plaque. FIRST-IN-HUMAN/EARLY REPORTS SUMMARY: Despite the absence of baseline calcification, serial imaging demonstrated increasing plaque volume before initiation of high-intensity rosuvastatin (20 mg daily). After treatment, low-density lipoprotein fell from 143 to 62 mg/dL, and plaque-volume growth slowed from ∼18.6% to 12.6% per year. A minute calcific focus (0.8 mm DISCUSSION: This longitudinal single-patient study provides imaging-based evidence that intensive statin therapy can decelerate noncalcified plaque progression, even in the absence of baseline calcium, as measured by quantitative AI-CCTA. NOVELTY: This is the first human case documenting statin-mediated slowing of noncalcified plaque in a CAC 0 patient with decade-long serial CCTA. TAKE-HOME MESSAGE: AI-quantified CCTA reveals subclinical atherosclerosis invisible to CAC 0 scoring and enables plaque-directed therapy monitoring in individual patients.
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