Evidence map›Paper›PMID 41348003›Full record

ReviewHematology. American Society of Hematology. Education Program2025

(Un) Diagnosing von Willebrand disease.

Michelle K Brenner, Pamela A Christopherson, Veronica H Flood

Abstract readReview
In one paragraph

Review in Hematology. American Society of Hematology. Education Program, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michelle K BrennerPediatric Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI.
Pamela A ChristophersonVersiti Blood Research Institute, Milwaukee, WI.
Veronica H FloodPediatric Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosis of von Willebrand disease (VWD) is a challenge due to variability in laboratory assays, variability in patient von Willebrand factor (VWF) levels, and variability in the different types of VWD. Because of these challenges, it can be difficult to make the diagnosis, especially in young children. On the other hand, older individuals may carry a diagnosis of VWD and not truly have VWD, creating the necessity for thoughtful evaluation of patients for whom "undiagnosing" VWD is appropriate. The most important factor is clinical bleeding history, although repeated laboratory testing and individual considerations are also critical. More research is needed on aging and VWF to best understand this challenge.

Indexed as

von Willebrand Diseasesvon Willebrand FactorFemaleHumansMalevon Willebrand Factor

Identifiers

PMID41348003
PMCPMC12891346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.