ArticleACS biomaterials science & engineering2026
Plasmid DNA Delivery Using a Stable Nanovesicle Platform: A Design-of-Experiments-Guided Investigation.
Mariana Köber, Irene González-Domínguez, Diego Valdospinos, Eduard Puente-Massaguer, Júlia Piqué-Ponti, David Piña, Laia Avilés-Domínguez, Ariadna Boloix, Miguel F Segura, Nora Ventosa and 1 more
Abstract read
In one paragraphArticle in ACS biomaterials science & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Mariana KöberInstitute of Materials Science of Barcelona (ICMAB-CSIC), Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.ORCID 0000-0001-9962-7900 Irene González-DomínguezDepartament d'Enginyeria Química Biològica i Ambiental, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.
Diego ValdospinosInstitute of Materials Science of Barcelona (ICMAB-CSIC), Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.
Eduard Puente-MassaguerDepartament d'Enginyeria Química Biològica i Ambiental, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.ORCID 0000-0002-2816-7051 Júlia Piqué-PontiInstitute of Materials Science of Barcelona (ICMAB-CSIC), Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.
David PiñaInstitute of Materials Science of Barcelona (ICMAB-CSIC), Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.
Laia Avilés-DomínguezInstitute of Materials Science of Barcelona (ICMAB-CSIC), Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.
Ariadna BoloixChildhood Cancer and Blood Disorders Group, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.ORCID 0000-0002-1648-5589 Miguel F SeguraChildhood Cancer and Blood Disorders Group, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
Nora VentosaInstitute of Materials Science of Barcelona (ICMAB-CSIC), Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.ORCID 0000-0002-8008-4974 Francesc GòdiaDepartament d'Enginyeria Química Biològica i Ambiental, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Delivering plasmid DNA (pDNA) into cells is essential for numerous biotechnological and biomedical applications. Among available nanocarriers, nonviral lipid-based vesicles are particularly promising for transfecting mammalian cells. Nevertheless, further development is required to create delivery systems that are both broadly effective across cell types and scalable for clinical use. Here, we explore stable nanovesicles composed of the sterol derivative cholesteryl
Indexed as
DNANanoparticlesPlasmidsTransfectionCholesterolGene Transfer TechniquesGreen Fluorescent ProteinsHEK293 CellsHumansCholesterolDNAGreen Fluorescent ProteinsDesign of Experimentsgreen fluorescent proteinHEK293 cell transfectionlipid-based nanovesiclesnonviral vectorsplasmid DNA deliveryquatsomes
Identifiers
PMID41347866
PMCPMC12801183
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LicenceCC BY
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