Evidence map›Paper›PMID 41347791›Full record

ArticlemBio2026

Echinocandin tolerance and persistence

Abigail A Harrington, Timothy J Nickels, Kyle W Cunningham

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Abigail A HarringtonDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-7001-4764
Timothy J NickelsDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA.
Kyle W CunninghamDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-6877-6321

Funding

CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
Mechanisms Promoting Cellular Tolerance to FungistatsR01AI153414 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CUNNINGHAM, KYLE W · 2020 to 2023
$1.6M
NIAID NIH HHS R01 AI153414NIGMS NIH HHS T32 GM007231
6 · The paper itself

Abstract

Upon exposure to echinocandins, growing yeast cells begin to accumulate cell wall damage and eventually die, resulting in therapeutic effects. While resistance to echinocandins is well studied, tolerance and persistence mechanisms that may also contribute to clinical failures and relapses remain understudied. In time-kill assays with micafungin IMPORTANCE: Treatment of fungal infections is often unsuccessful. Potential causes of antifungal failure include tolerance and persistence, which are poorly understood processes used by fungal pathogens to survive antifungal treatment. This study utilizes detailed experimental protocols and genome-wide screens to discover how

Indexed as

Antifungal AgentsCalcineurinCandida glabrataDrug Resistance, FungalEchinocandinsSignal TransductionFungal ProteinsGene Expression Regulation, FungalGene Knockout TechniquesMicafunginTacrolimusAntifungal AgentsCalcineurinEchinocandinsFungal ProteinsMicafunginTacrolimusantifungal resistanceCandida albicansCandida glabratapersistencetolerance

Identifiers

PMID41347791
PMCPMC12802179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.