Evidence map›Paper›PMID 41347695›Full record

ArticlePediatric pulmonology2025

Increased Mean Airway Pressure Is Associated With Successful Transition to a Portable Home Ventilator in Patients With Grade 3 Bronchopulmonary Dysplasia.

Robin L McKinney, Joseph M Collaco, Amit Agarwal, Christopher D Baker, Manvi Bansal, Matthew Douglass, Pamela S Griffiths, Kathleen E Hannan, Martin Keszler, Matthew J Kielt and 9 more

Erratum issuedAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Robin L McKinneyDepartment of Pediatrics, Division of Critical Care Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0002-6107-0841
Joseph M CollacoDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-2581-4372
Amit AgarwalDepartment of Pediatrics, Arkansas Children's Research Institute, Little Rock, Arkansas, USA.
Christopher D BakerDepartment of Pediatrics, Section of Pulmonary and Sleep Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0002-1171-563X
Manvi BansalDepartment of Pediatrics, Division of Pediatric Pulmonology and Sleep Medicine, Childre's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-3030-7754
Matthew DouglassDepartment of Pediatrics, Division of Neonatology, School of Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0001-6271-455X
Pamela S GriffithsDepartment of Child Health, Division of Neonatology, Phoenix Children's Hospital, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, USA.
Kathleen E HannanDepartment of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Martin KeszlerDepartment of Pediatrics, Division of Neonatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Matthew J KieltDepartment of Pediatrics, Division of Neonatology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-4568-9070
Winston ManimtimDivision of Neonatology, Children's Mercy-Kansas City, University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA.
Sharon Mcgrath MorrowDivision of Pulmonary and Sleep Medicine, Children Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-1576-5394
Audrey MillerDepartment of Pediatrics, Division of Neonatology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Meaghan A RansomDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Roopa SiddaiahDepartment of Pediatrics, Division of Pulmonology, Penn State Health Children's Hospital, Hershey, Pennsylvania, USA.
Abhineet M SharmaDepartment of Pediatrics, Division of Neonatology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Joshua TanzerDepartment of Pediatrics, Division of Critical Care Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Laurie C EldredgeDepartment of Pediatrics, Division of Pulmonary and Sleep Medicine, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA.
Bronchopulmonary Dysplasia Collaborative

Funding

Clinical and Biochemical Features of Metabolic Dysregulation in Formerly Preterm ChildrenR01HL169859 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric Douglas Austin, Joseph Michael Collaco · 2024 to 2026
$2.2M
Lung Injury Biomarkers to Endotype Respiratory Trajectories in Established Bronchopulmonary Dysplasia: The LIBERATE-BPD StudyK23HL175207 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Matthew Kielt · 2025 to 2026
$358k
NHLBI NIH HHS K23 HL175207NHLBI NIH HHS R01 HL169859The authors received no specific funding for this work.
6 · The paper itself

Abstract

objectivesAn estimated 23% of children with grade 3 bronchopulmonary dysplasia (BPD) require tracheostomy for long term positive pressure ventilation. Transition from an intensive care unit (ICU) ventilator to a portable home ventilator (PHV) is one of the key steps in the process of discharging a patient home. The objective of this study was to identify clinical factors and ventilator settings associated with successful transition to a PHV in infants with grade 3 BPD. STUDY

designWe performed a retrospective record review of 74 ventilator-dependent infants with grade 3 BPD hospitalized at 15 centers within the BPD Collaborative who transitioned to PHV between March 2021 and March 2023. Hierarchical cluster analysis of patient demographics and ICU ventilator settings at the time of transition was identify similar groups and compare factors associated with successful transitions.

resultsPatients with higher mean airway pressure (MAP) on the PHV compared with the MAP on their ICU ventilator were more likely to successfully transition on the first attempt, had fewer days from their first attempt until successful transition, and transitioned at an earlier postmenstrual age than patients with a lower MAP on their PHV. Cluster analysis of baseline ICU ventilator settings did not predict successful transition to PHV.

conclusionsWe conclude that higher PHV pressures may enable patients with severe BPD to transition to a PHV. Premature weaning of ventilator pressures may be associated with prolonged need for an ICU ventilator.

Indexed as

Bronchopulmonary DysplasiaPositive-Pressure RespirationVentilators, MechanicalFemaleHome Care ServicesHumansInfantInfant, NewbornMaleRetrospective Studiesbronchopulmonary dysplasiachronic lung disease of prematurityprematurity

Identifiers

PMID41347695
PMCPMC13551491

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.