ArticleJournal of cosmetic dermatology2025
Anti-Inflammatory and Pro-Healing Effects of Human Plasma-Derived Exosomes in a Murine Wound Model.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Anti-Inflammatory and Pro-Healing Effects of Human Plasma-Derived Exosomes in a Murine Wound Model.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExosomes have emerged as key mediators in regenerative medicine because of their ability to facilitate intercellular signaling and promote tissue renewal. Exosomes from various origins have demonstrated efficacy in tissue regeneration.
aimsTo explore the potential of plasma-derived exosomes (PDEs) in wound healing through in vitro analyses and an in vivo mouse model. PATIENTS/
methodsPDEs were isolated from blood and characterized using a nanoparticle assay. Human dermal fibroblasts (HDFs) were treated with PDEs at different concentrations to assess cell proliferation, migration, and gene expression. For in vivo evaluation, 8-mm full-thickness wounds were created on C57BL/6 mice and treated with either subcutaneous injection or topical smearing of PDEs at low (5 × 10
resultsPDEs promoted HDF proliferation and migration in vitro, with significantly higher cell migration rates (38.2, 40.2%) compared to controls (17.8%, p < 0.001). Gene expression analysis revealed the upregulation of collagen synthesis markers (COL1A1) and the downregulation of degradation markers (MMP1). Both subcutaneous injection and topical smearing methods accelerated wound healing in vivo, with closure rates of 91.8%-96.5% in treated groups versus 70.9%-72.6% in controls by day 8. Treatment increased the expression of regenerative markers (Fgf1, Fn1) while reducing the levels of inflammatory markers (Il6, Ptgs2).
conclusionPDEs promote wound healing by enhancing cell proliferation, stimulating collagen synthesis, and modulating inflammatory responses. Both subcutaneous injection and topical smearing were effective.
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Registered trials
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