Evidence map›Paper›PMID 41347607›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Elevator-Like Hollow Channels in Porous Scaffolds Accelerate Vascularized Bone Regeneration via NETs-Fibrin-Mediated Macrophage Recruitment.

Guifang Wang, Rongpu Liu, Huijing Ma, Shuhan Duan, Guangzheng Yang, LingXi Meng, Yuqin Qiao, Dongqiang Song, Wenjie Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guifang WangDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Rongpu LiuDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Huijing MaDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Shuhan DuanDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Guangzheng YangDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
LingXi MengDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Yuqin QiaoMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, China.
Dongqiang SongDepartment of Hepatobiliary Oncology, Zhongshan Hospital, Fudan University, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Wenjie ZhangDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.ORCID https://orcid.org/0000-0002-7753-695X

Funding

Fundamental Research Funds for the Central Universities YG2023ZD16National Natural Science Foundation of China 32171344National Natural Science Foundation of China 82001011National Natural Science Foundation of China 82022015National Natural Science Foundation of China 82100966National Natural Science Foundation of China 82370923
6 · The paper itself

Abstract

Developing viable tissue-engineered constructs for large-scale bone defects remains a fundamental challenge due to the difficulty of establishing adequate vascular networks. Channel structures act as biological elevators, rapidly promoting vascularization in scaffold materials. However, the underlying mechanisms driving this accelerated process remain unclear. In this study, porous silk fibroin (SF) scaffolds with hollow channels are engineered to investigate their vascularization-accelerating mechanisms. It is demonstrated that the channels enable the rapid infiltration of fibrinogen and platelets. This initiates a sequential biological cascade involving neutrophil recruitment, the formation of neutrophil extracellular traps (NETs), and subsequent macrophage migration. This coordinated process generates a provisional yet bioactive matrix that promotes directional vascular invasion. Leveraging the architecture of the hollow channels, a biomimetic system is developed that rapidly establishes provascular microenvironments featuring macrophage-populated NETs-fibrin networks through blood clot preloading. This combined structural and biological strategy enhances angiogenic-osteogenic coupling through spatially controlled bone morphogenetic protein-2 (BMP-2) presentation, significantly improving bone regeneration and providing a clinically translatable solution for vascularized bone regeneration. This study not only elucidates the mechanistic link between scaffold architecture and host immune response, but also establishes a novel paradigm for biomaterial design in hard tissue engineering.

Indexed as

Bone RegenerationExtracellular TrapsFibrinMacrophagesTissue ScaffoldsAnimalsFibroinsHumansMiceNeovascularization, PhysiologicOsteogenesisPorosityTissue EngineeringFibrinFibroinsangiogenic–osteogenic couplingbone regenerationneutrophil extracellular trapssilk fibroin scaffoldvascularization

Identifiers

PMID41347607
PMCPMC12904018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.