Evidence map›Paper›PMID 41347523›Full record

ArticleAntimicrobial agents and chemotherapy2026

Activity of aztreonam-avibactam, cefiderocol, and cefepime-taniborbactam against a global collection of genetically characterized metallo-β-lactamase-producing Enterobacterales.

Mariana Castanheira, John H Kimbrough, Gina M Morgan, Maura Karr, Helio S Sader

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Risk factors for infection in NDM-colonized patients and applicability of the Giannella Risk Score.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  3. Microbiology spectrum · 2026
    Article
  4. Cefiderocol nonsusceptibility among carbapenem-resistantAntimicrobial agents and chemotherapy · 2026
    Article
  5. Article
  6. Article
  7. Antimicrobial agents and chemotherapy · 2026
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mariana CastanheiraElement Materials Technology (JMI Laboratories), North Liberty, Iowa, USA.ORCID 0000-0003-0126-1782
John H KimbroughElement Materials Technology (JMI Laboratories), North Liberty, Iowa, USA.ORCID 0000-0002-0457-1543
Gina M MorganElement Materials Technology (JMI Laboratories), North Liberty, Iowa, USA.
Maura KarrElement Materials Technology (JMI Laboratories), North Liberty, Iowa, USA.
Helio S SaderElement Materials Technology (JMI Laboratories), North Liberty, Iowa, USA.ORCID 0000-0001-7022-6644

Funding

Pfizer 24-PZR-03Pfizer various
6 · The paper itself

Abstract

We evaluated the activity of aztreonam-avibactam and comparators tested against 490 MBL-producing Enterobacterales isolates collected in 27 countries during 2019-2022. The most common MBL was NDM-1, which was detected among 307 isolates. The genes encoding NDM-5 and VIM-1 were detected among 68 and 53 isolates, respectively. Other 14 MBL-encoding genes or combinations were detected among 62 isolates. Mexico, Turkey, and Greece had the highest number of isolates (60, 59, and 57, respectively). All isolates were susceptible to aztreonam-avibactam (MIC

Indexed as

Anti-Bacterial AgentsAzabicyclo CompoundsAztreonambeta-LactamasesBorinic AcidsCefepimeCephalosporinsEnterobacteriaceaeCarboxylic AcidsCefiderocolDrug CombinationsDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsavibactamAzabicyclo CompoundsAztreonambeta-LactamasesBorinic AcidsCarboxylic AcidsCefepimeCefiderocolCephalosporinsDrug CombinationstaniborbactamEnterobacteralesmetallo-β-lactamasesnew antimicrobial agentsresistance mechanismssusceptibility

Identifiers

PMID41347523
PMCPMC12777553

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.