Evidence map›Paper›PMID 41347522›Full record

ArticleAntimicrobial agents and chemotherapy2026

The molecular basis of intrinsic resistance to azoles in

Michaela Lackner, Stephanie Toepfer, Mikhail V Keniya, Carlos Lax, Francisco E Nicolas, Victoriano Garre, Christoph Müller, Katharina Rosam, Lisa-Maria Zenz, Lucia Cesarini and 3 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michaela Lackner *Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0001-9073-2886
Stephanie Toepfer *Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0009-0005-0205-1666
Mikhail V KeniyaFaculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, Otago, New Zealand.
Carlos LaxDepartamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, Murcia, Spain.
Francisco E NicolasDepartamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, Murcia, Spain.
Victoriano GarreDepartamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, Murcia, Spain.ORCID 0000-0001-7605-1726
Christoph MüllerDepartment of Pharmacy - Center for Drug Research, Ludwig-Maximilians Universität München, Munich, Bavaria, Germany.ORCID 0000-0002-1163-2527
Katharina RosamInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Lisa-Maria ZenzInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Lucia CesariniDepartment of Chemistry, Biology and Biotechnology, Università degli Studi di Perugia, Perugia, Umbria, Italy.
Ulrike BinderInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Joel D A TyndallSchool of Pharmacy, University of Otago, Dunedin, Otago, New Zealand.
Brian C Monk *Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, Otago, New Zealand.ORCID 0000-0003-2264-3480

Funding

Agencia Estatal de Investigación 10.13039/501100011033Austrian Science Fund P32329-BEuropean Regional Development Fund PID2021-124674NB-I00Fundación Séneca 21969/PI/22Health Research Council of New Zealand 16/232 and 19/397Royal Society of New Zealand 18-UOO-007-CSG
6 · The paper itself

Abstract

The fungal disease mucormycosis, while generally regarded as rare and not transmitted between individuals, has become increasingly prevalent in disaster areas, among the immunocompromised, and in diabetics especially in response to COVID-19. Treatment options are limited. These include debridement of necrotizing tissue followed by complicated multicomponent therapies with amphotericin B and selected azole drugs, usually having poor outcomes. Mucormycetes are intrinsically resistant to the widely used short-tailed azole drugs fluconazole and voriconazole, but susceptible to the long-tailed, though expensive, azole posaconazole. Knowledge of the crystal structure of

Indexed as

Antifungal AgentsAzolesDrug Resistance, FungalRhizopusFluconazoleFungal ProteinsHumansMicrobial Sensitivity TestsMucormycosisSaccharomyces cerevisiaeSterol 14-DemethylaseTriazolesVoriconazoleAntifungal AgentsAzolesFluconazoleFungal ProteinsposaconazoleSterol 14-DemethylaseTriazolesVoriconazoleamino acid substitutionantifungal resistancemucoralesresistance mechanism

Identifiers

PMID41347522
PMCPMC12777571

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.