ArticleJournal of clinical practice and research2025
Prognostic Factors and Survival Data of Stage I Lung Cancer: A Single-Center Experience.
Article in Journal of clinical practice and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Even in stage I lung cancer, the heightened risk of recurrence may lead to diminished survival rates. Only a few reports on prognostic factors have been published for stage I disease using the most recent staging system. This study was designed to identify predictive factors of recurrence and survival in early-stage lung cancer (LC) staged according to the eighth edition of the Tumor, Node, Metastasis (TNM) classification. Materials and Methods: The clinicopathological characteristics, treatment, and follow-up data of 100 stage I patients monitored between 2013 and 2023 were retrospectively reviewed. The association between clinicopathological factors and survival was analyzed to identify prognostic factors. Results: The median age was 61 years (range, 35-76). All patients had a histologic diagnosis of non-small cell lung cancer, with 62% being adenocarcinoma. During a median follow-up of 40.3 months (range, 1-183.5), 20 patients experienced recurrence and 16 died. The two-year and five-year disease-free survival (DFS) rates were 81% and 73%, respectively, while overall survival (OS) rates for the same periods were 86% and 77%. Multivariate analysis revealed that a smoking history greater than 40 pack-years (p=0.021) and perineural invasion (PNI) (p=0.049) were predictors of recurrence, while the presence of lymphovascular invasion (LVI) was significantly associated with OS (p=0.019). Conclusion: Smoking significantly increases the risk of LC development and recurrence, making it crucial to promote smoking cessation. Patients with positive LVI or PNI in early-stage LC should be monitored more closely, although further research is warranted.
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