ReviewEuropean cardiology2025
The Coronary Microcirculation Re-explored: Pathophysiological Insights and Clinical Implications.
Review in European cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary microvascular dysfunction (CMD) is being increasingly recognised as a significant contributor to myocardial ischaemia, particularly in patients without obstructive coronary artery disease. This review explores the anatomy and physiology of the coronary microcirculation, emphasising the role of endothelial dysfunction and endothelin-1 in CMD pathogenesis. We discuss diagnostic approaches, including invasive and non-invasive techniques, such as PET, cardiac MRI and intracoronary physiological testing. Current management strategies focus on risk factor modification and tailored pharmacotherapy, with emerging therapies targeting endothelin pathways. A comprehensive understanding of CMD is essential for improving diagnostic accuracy and developing effective treatments for patients presenting with ischaemic symptoms absent of angiographic evidence of coronary obstruction.
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