ArticleFrontiers in pharmacology2025
Pharmacokinetics of mycophenolic acid in plasma and peripheral blood mononuclear cells and its relationship with activity of inosine monophosphate dehydrogenase in Chinese adult kidney allograft recipients.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Simultaneous Quantification of Mycophenolic Acid and Its Glucuronide Metabolite in PBMCs from Kidney Transplant Recipients by LC-MS/MS.Drug design, development and therapy · 2026Article
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8 authors.
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Abstract
Aims: We aimed to study the pharmacokinetics (PK) of mycophenolic acid (MPA) in plasma and peripheral blood mononuclear cells (PBMCs) and the relationship of MPA in plasma and PBMC with activity of inosine monophosphate dehydrogenase (IMPDH) in Chinese kidney allograft recipients. Methods: Plasma and PBMC samples were collected 0-12 h after administration of mycophenolate mofetil (MMF) or enteric-coated mycophenolate sodium (EC-MPS) 2 weeks after initiation of immunosuppressive therapy. MPA concentrations in plasma and PBMCs and IMPDH activity were determined using liquid chromatography-mass spectrometry. The PK and pharmacodynamic parameters was estimated. The relationship between plasma and PBMC MPA levels and IMPDH activity was determined using the inhibitory E Results: Totally 24 patients receiving MMF and 19 patients receiving EC-MPS were included in the study. A significant positive correlation was observed between the C Conclusion: Measurement of MPA concentration and IMPDH activity in PBMCs serves as a complementary method to routine clinical therapeutic drug monitoring, which provide basis for the individual therapy of MPA in Chinese kidney allograft recipients.
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