Evidence map›Paper›PMID 41347138›Full record

ArticleFrontiers in endocrinology2025

The hypothalamic effects of PACAP on the hypothalamic-pituitary-gonadal axis in male mice.

Péter Faludi, Klaudia Barabás, Ferenc Lengyel, Ildikó Udvarácz, Dániel Pham, Olivér Kisjós, Zsuzsanna Nagy, Dóra Reglődi, Gergely Kovács

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In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Péter FaludiInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Klaudia BarabásInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Ferenc LengyelInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Ildikó UdvaráczInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Dániel PhamDepartment of Anatomy, HUN-REN-PTE PACAP Research Team, Medical School, University of Pécs, Pécs, Hungary.
Olivér KisjósInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Zsuzsanna NagyInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.
Dóra ReglődiDepartment of Anatomy, HUN-REN-PTE PACAP Research Team, Medical School, University of Pécs, Pécs, Hungary.
Gergely KovácsInstitute of Physiology, Medical School, University of Pécs, Pécs, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the vasoactive intestinal peptide (VIP) neuropeptide family and plays a role in the regulation of several releasing hormones and tropic hormones. The hypothalamic-pituitary-gonadal (HPG) axis governs the synthesis and the release of sex hormones and the gametogenesis in all mammals. While the effects of PACAP on fertility is well-documented in females, much less data are available in males. The aim of our study was to examine potential structural and expressional changes in the hypothalamus that might underlie the fertility deficits observed in male PACAP knockout (KO) mice. To this end, we performed immunofluorescent, immunohistochemical and RNAscope

Indexed as

GonadsHypothalamo-Hypophyseal SystemHypothalamusPituitary Adenylate Cyclase-Activating PolypeptideAnimalsEstrogen Receptor alphaGonadotropin-Releasing HormoneHypothalamic-Pituitary-Gonadal AxisKisspeptinsMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsReceptors, AndrogenAdcyap1 protein, mouseEstrogen Receptor alphaGonadotropin-Releasing HormoneKisspeptinsPituitary Adenylate Cyclase-Activating PolypeptideReceptors, Androgenandrogen receptorestrogen receptor alphaGnRHkisspeptinPACAP

Identifiers

PMID41347138
PMCPMC12673620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.