Evidence map›Paper›PMID 41347110›Full record

ArticleDepression and anxiety2025

Shared and Unique Structural Covariance Connectivity in Comorbidity of Obsessive-Compulsive Disorder and Major Depressive Disorder.

Hongyu Du, Feng Gao, Yan Han, Chuman Xiao, Qian Li, Douyu Zhang, Zhiyan Wang, Qianmei Yu, Sainan Cai, Jie Fan and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Depression and anxiety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hongyu DuMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Feng GaoMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Yan HanMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Chuman XiaoMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Qian LiMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Douyu ZhangMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Zhiyan WangMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Qianmei YuMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Sainan CaiDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Jie FanMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.ORCID 0009-0000-7598-6095
Xiongzhao ZhuMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.ORCID 0000-0002-7573-0740

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The comorbidity of obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) is a prevalent clinical phenomenon, which is associated with greater symptom severity, suicide risk, and poorer treatment outcomes. However, the neural basis of this comorbidity remains unclear. The aim of this study was to investigate the common and unique neural basis of comorbidity compared with OCD and MDD alone. Methods: A total of 67 patients with comorbid OCD and MDD, 89 patients with OCD alone, 94 patients with MDD alone, and 94 healthy controls (HCs) completed the acquisition of T1-weighted structural images and were included in the present study. The gray matter volume of each brain region in the AAL116 atlas was calculated, based on which the structural covariance between each pair of brain regions was measured. One-way ANCOVA were performed to explore the structural covariance differences among the four groups. Results: Compared with HC, patients with comorbidity and patients with OCD or MDD alone showed some common altered structural connections ( Conclusions: Compared with OCD or MDD alone, comorbidity showed both common and unique altered structural covariant connections of gray matter structure. The unique structural connections observed in comorbidity were concentrated between the cerebellum and other brain regions. These findings highlight the crucial role of the cerebellum in the neural basis of comorbid OCD and MDD.

Indexed as

BrainGray MatterMajor Depressive DisorderObsessive-Compulsive DisorderAdultComorbidityFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedYoung Adultcomorbiditymajor depressive disorderobsessive–compulsive disorderstructural covariance network

Identifiers

PMID41347110
PMCPMC12674874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.