ReviewFrontiers in oncology2025
Advances in modeling gastric intestinal metaplasia: a comprehensive review of experimental models and mechanistic insights.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Organoid models: applications and research advances in gastric cancer.Frontiers in oncology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial cells within the gastric corpus mucosa exhibit a dynamic response to injury, characterized by alterations in gene transcription, cellular phenotype, and tissue organization, collectively termed metaplasia. Among these changes, gastric intestinal metaplasia (GIM) represents one of the most prevalent precancerous lesions associated with intestinal-type gastric cancer (GC). This pathological progression typically evolves through a sequence of stages: chronic atrophic gastritis, intestinal metaplasia, atypical hyperplasia, and ultimately, GC. A deeper understanding of GIM is crucial for advancing diagnostic and therapeutic strategies in GC management. Despite its clinical significance, progress in elucidating the underlying mechanisms of GIM has been limited, primarily due to the lack of reliable and reproducible animal models that accurately recapitulate this condition. This review systematically examines the existing mouse, rat, and organoid models utilized for GIM research, providing critical insights into various methodological approaches and potential mechanisms. Specifically, we investigate five pivotal aspects of pyloric metaplasia and GIM:
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