ArticleFrontiers in oncology2025
Risk stratification for intracranial infection after high-grade gliomas surgery: a nomogram development and validation study.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Advances and Future Expectations in Oncolytic Virus Therapy for Glioblastoma: A Systematic Review of Clinical Trials.Clinical Medicine Insights. Oncology · 2026Review
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Abstract
Background: Intracranial infection (ICI) is a severe complication following high-grade gliomas (HGGs) surgery, leading to increased morbidity and mortality. This study aimed to identify risk factors for postoperative ICI and to develop and validate a nomogram for predicting its occurrence, providing a tool to guide clinical prevention. Methods: The clinical data of 104 patients who underwent surgery for HGGs between January 2017 and August 2024 were retrospectively analyzed. Patients were randomly divided into a training set (n=72) and a validation set (n=32). Risk factors for ICI were assessed using univariate and multivariate logistic regression analyses. A predictive nomogram was constructed based on the identified independent risk factors and evaluated for its performance. Results: Sixteen of the 104 patients (15.4%) developed a postoperative ICI. Multivariate logistic regression analysis identified a preoperative Karnofsky Performance Status (KPS) score ≤ 70 (OR = 16.55, 95% CI: 2.57-106.54, Conclusion: A low preoperative KPS score and prolonged drainage tube placement are significant independent predictors of ICI after glioblastoma surgery. The nomogram developed in this study provides a simple and accurate tool for risk stratification, which can assist clinicians in identifying high-risk patients and implementing targeted preventive measures.
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