Evidence map›Paper›PMID 41347020›Full record

ArticleFrontiers in physiology2025

Evaluation of donor's hormonal profile according to sex and age.

M M de Assis Ramos, F Y Ricardo-da-Silva, M Vidal-Dos-Santos, M J Vos, P J Ottens, G J Nieuwenhuijs-Moeke, C J Correia, S J L Bakker, L F P Moreira, H Leuvenink and 2 more

Abstract read
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Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

M M de Assis RamosLaboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulação (LIM-11), Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
F Y Ricardo-da-SilvaLaboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulação (LIM-11), Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
M Vidal-Dos-SantosLaboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulação (LIM-11), Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
M J VosDepartment of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
P J OttensDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
G J Nieuwenhuijs-MoekeDepartment of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
C J CorreiaLaboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulação (LIM-11), Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
S J L BakkerDepartment of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
L F P MoreiraLaboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulação (LIM-11), Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
H LeuveninkDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
A C Breithaupt-FaloppaLaboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulação (LIM-11), Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
for TransplantLines investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Successful organ transplantation depends on several factors, including donor and recipient sex and age. Experimental data show that donor inflammatory status can be influenced by sex hormones, and, after brain death, there are significant differences in organ quality. Sex hormones also influence the immune system during different life stages, for example, during menopause there is a significant reduction in estrogen levels. Thus, the primary aim of this study is to evaluate the steroid profile of human donors after brain death. We performed a retrospective observational case-control study and selected samples from living (LD) and brain-dead (BD) donors from the TransplantLines Biobank and Cohort Study. Donors were stratified by age as Young (Y) from 20-40 years and Old (O), older than 55 years. Serum steroidal hormones from one hundred donors were analysed through LC-MS (Liquid Chromatography-Mass Spectrometry). In BD-females, cortisol and estradiol decreased significantly (

Indexed as

agebrain deathcortisolestradiolhormonesprogesteronesextestosterone

Identifiers

PMID41347020
PMCPMC12673268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.