ArticleHealth science reports2025
The Safety and Efficacy of an Immunomodulator Garlic-Based Cream (LeishG1) for Treating Uncomplicated Cutaneous Leishmaniasis: A Single-Blind, Multi-Center Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Cutaneous leishmaniasis (CL) is a major problem in developing nations, particularly in the Middle East. Novel herbal treatment options may provide a safe alternative associated with favorable outcomes in CL lesion healing. Here, we report the findings of a clinical study evaluating the safety and efficacy of an immunomodulator garlic-based cream (LeishG1) for treating uncomplicated CL. Methods: Volunteers diagnosed with CL were randomly assigned to either apply LeishG1 cream twice daily for 2 months ( Results: The current study enrolled 60 CL patients, of whom 27 subjects with 30 lesions and 20 subjects with 27 lesions completed treatment courses with LeishG1 or Glucantime®, respectively. A complete cure at 2 months' follow-up was observed in 56% ( Conclusion: According to both the ITT and PP analyses, there was no significant difference in cure rate between the Glucantime® and LeishG1 groups. Regarding safety, LeishG1 raised no considerable safety concern, neither in CL patients nor in healthy volunteers. These findings suggest that LeishG1 cream is a safe and effective treatment option for CL. Registered in: Iranian Registry of Clinical Trials (IRCTID: IRCT20180115038383N1) (https://irct.behdasht.gov.ir/trial/29057).
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