ArticleCureus2025
A Rare Autopsy Finding of Müllerian and Renal Agenesis Linked to Suspected AMHR2 Pathway Disruption.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
We present a rare incidental finding of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome identified during the autopsy of a reproductive-aged woman who died in a motor vehicle accident. In situ examination showed the absence of both the uterus and cervix, with the vaginal canal ending in a blind pouch that measured 7.0 × 6.0 cm, with a depth of 4 cm. Both ovaries were present and positioned high near the iliac vessels, demonstrating multiple cysts upon cut surfaces. The bilateral fallopian tubes were absent in their entirety. The right kidney, along with its hilar vessels and ureter, was also absent, while the left kidney and its associated structures were present but slightly enlarged. The bilateral adrenal glands were normally positioned and grossly unremarkable. The combination of absent uterus, cervix, and right kidney, along with ascended ovaries, is consistent with a developmental abnormality involving the anti-Müllerian hormone (AMH) pathway and potential disruption of the
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