Evidence map›Paper›PMID 41346861›Full record

ArticleNAR molecular medicine2025

Impaired nick recognition and ligation efficiency by LIG1 K845N variant linked to Huntington's disease.

Jacob Ratcliffe, Camden E Lerner, Kanal Balu, Surajit Chatterjee, Kar Men Lee, Melike Caglayan

Abstract read
In one paragraph

Article in NAR molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jacob RatcliffeDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, United States.
Camden E LernerDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, United States.
Kanal BaluDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, United States.
Surajit ChatterjeeDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, United States.
Kar Men LeeDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, United States.ORCID https://orcid.org/0009-0001-5685-4895
Melike CaglayanDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, United States.ORCID https://orcid.org/0000-0003-1107-1042

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
DNA ligase activities during base excision repair coordinationR35GM147111 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MELIKE CAGLAYAN · 2022 to 2026
$2.1M
NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R35 GM147111
6 · The paper itself

Abstract

DNA ligase 1 (LIG1) joins broken strand breaks and seals Okazaki fragments during DNA repair and replication. Huntington's disease (HD)-associated mutation in the

Identifiers

PMID41346861
PMCPMC12673853

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.