ArticleInternational journal of endocrinology2025
Association Between Serum Ferritin Levels and the Risk of Kidney Stones in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study.
Article in International journal of endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Prior research has identified a significant correlation between elevated serum ferritin (SF) levels and comorbidities in Type 2 diabetes mellitus (T2DM) patients. However, the association between SF levels and kidney stone occurrence in T2DM remains unexplored. This study aimed to assess the relationship between SF levels and kidney stone risk in T2DM patients. Methods: This study collected data from 50,583 patients with T2DM who received treatment at the First Affiliated Hospital of University of Science and Technology of China from December 2015 to December 2023. Ultimately, 1024 eligible patients were included for analysis. Multivariable logistic regression models were used to determine the odds ratio (OR) and 95% confidence interval (95% CI) for the association between SF and kidney stones. A multivariable-adjusted restricted cubic spline model was constructed to establish the OR curves to examine the possible nonlinear dose-response association between SF and kidney stones. Results: Of 1024 patients included in this study (mean age, 56.31 ± 9.82 years-old; 686 [67.0%] male), 148 (14.5%) reported having kidney stones, while 876 (85.5%) did not. After adjusting for potential confounders, the SF levels were associated with kidney stones (OR = 1.001; 95% CI, 1.000-1.002; Conclusion: Elevated SF levels are associated with kidney stones in T2DM patients.
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