ArticleFrontiers in public health2025
Transmission characteristics of tuberculosis in the high-TB-burden region of Southwest China.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Whole genome sequencing (WGS) can provide valuable insights into the transmission patterns of Methods: We conducted a retrospective study using strains isolated from L County between January 2019 and July 2020. Demographic data of patients were retrieved from National Tuberculosis Information Management System. A whole genome sequencing-based clustering analysis was performed to assess the transmission characteristics of pulmonary TB in L County. Univariate and multivariate logistic regression analyses were employed to identify potential risk factors associated with clustering. Results: A total of 143 strains from 136 confirmed TB cases were available for analysis, among them 74.26% of Conclusion: A significant proportion of tuberculosis cases in L County are attributed to recent transmission occurring within communities or neighborhoods across townships for both sensitive and drug-resistant TB. These findings suggest that an active case-finding strategy should be implemented in this area to identify patients at the early stages. Furthermore, active screening should not only target key populations such as close household contacts or old population but also extend to all residents over 15 years. Improving chemotherapy treatment quality and patient follow-up is essential in L County.
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