ArticleFrontiers in nutrition2025
Plant-based dietary index on the Mediterranean and a vegan diet: a secondary analysis of a randomized, cross-over trial.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03698955 (A Randomized, Cross-Over Trial on the Effects of a Low-Fat Vegan Diet Versus a Mediterranean Diet on Body Weight), which is not on this map. Not yet cited in PubMed.
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A Randomized, Cross-Over Trial on the Effects of a Low-Fat Vegan Diet Versus a Mediterranean Diet on Body Weight
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7 authors.
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Abstract
Objective: The plant-based diet index (PDI) has been proposed as a gauge of diet healthfulness. This study assessed the relationship between the PDI, and the "healthful" hPDI and "unhealthful" uPDI, and weight loss in the context of Mediterranean and vegan diets in overweight adults. Methods: In a cross-over trial, 62 overweight adults followed a Mediterranean and a low-fat vegan diet for 16 weeks in random order, separated by a 4-week washout. Body weight was the primary outcome. In a secondary analysis, three-day dietary records were analyzed, PDI indices were calculated. Their correlation with changes in body weight was assessed, using Spearman correlations. Results: Compared with no change on the Mediterranean diet, PDI significantly increased on the vegan diet; effect size: +7.6 (95% CI +4.1 to +11.0); Conclusion: These findings suggest that, replacing animal products even with the "unhealthful" plant-based foods on a vegan diet was associated with weight loss. Clinical trial registration: ClinicalTrials.gov, identifier NCT03698955.
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