Evidence map›Paper›PMID 41346636›Full record

ArticleFrontiers in immunology2025

Follicle-like niches outside the cortex? 3D phase-contrast µCT revealed medullary B cell nodules in mucosa-draining lymph nodes.

Paul Schütz, Florian L Schwarzenberg, Lennert J Weber, Jörg U Hammel, Bente Siebels, Paula Nissen, Nenya Leising, Katja J Jarick, Bernd Walkenfort, Sarah C Irvine and 5 more

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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Paul SchützINI-Research, Group for Interdisciplinary Neurobiology and Immunology, University of Hamburg, Hamburg, Germany.
Florian L SchwarzenbergINI-Research, Group for Interdisciplinary Neurobiology and Immunology, University of Hamburg, Hamburg, Germany.
Lennert J WeberINI-Research, Group for Interdisciplinary Neurobiology and Immunology, University of Hamburg, Hamburg, Germany.
Jörg U HammelInstitute for Materials Physics, Helmholtz-Zentrum Hereon, Geesthacht, Germany.
Bente SiebelsSection Mass Spectrometry and Proteomics, Center for Diagnostics, University Medical-Center Hamburg-Eppendorf, Hamburg, Germany.
Paula NissenSection Mass Spectrometry and Proteomics, Center for Diagnostics, University Medical-Center Hamburg-Eppendorf, Hamburg, Germany.
Nenya LeisingINI-Research, Group for Interdisciplinary Neurobiology and Immunology, University of Hamburg, Hamburg, Germany.
Katja J JarickINI-Research, Group for Interdisciplinary Neurobiology and Immunology, University of Hamburg, Hamburg, Germany.
Bernd WalkenfortImaging Center Essen (IMCES), Electron Microscopy Unit (EMU), Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Sarah C IrvineInstitute for Materials Physics, Helmholtz-Zentrum Hereon, Geesthacht, Germany.
Jasmin BartlINI-Research, Group for Interdisciplinary Neurobiology and Immunology, University of Hamburg, Hamburg, Germany.
Julia HerzenBiomedical Imaging Physics, TUM School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany.
Christian LohrDivision of Neurophysiology, University of Hamburg, Hamburg, Germany.
Clemens WülfingINI-Research, Group for Interdisciplinary Neurobiology and Immunology, University of Hamburg, Hamburg, Germany.
Stephan HenneINI-Research, Group for Interdisciplinary Neurobiology and Immunology, University of Hamburg, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study identifies and characterizes previously unrecognized medullary B cell niches within murine mucosa-draining lymph nodes (LNs), challenging the conventional understanding of LN architecture. Utilizing advanced imaging techniques, including synchrotron radiation-based phase-contrast micro-computed tomography (SRµCT), correlated high-resolution electron microscopy and immunohistochemistry (IHC), we revealed spherical to ovoid structures termed

Indexed as

B-LymphocytesLymph NodesMucous MembraneAnimalsImaging, Three-DimensionalMiceMice, Inbred C57BLX-Ray MicrotomographyagingB cell microenvironmenthigh endothelial venule (HEV)lymph node nicheslymphocyte homingmedullamucosal immunityX-ray microtomography

Identifiers

PMID41346636
PMCPMC12672535

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.