ArticleMedComm2025
Personalized and Tumor Informed Circulating Tumor DNA Assay for Molecular Residual Disease Monitoring of Solid Malignancies.
Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Article
- Multidrug resistance in cancer: current understandings and future perspective.Molecular biomedicine · 2026Review
- Circulating tumor DNA in neoadjuvant therapy for solid tumors.Frontiers in oncology · 2026Review
- Personalized and Tumor Informed Circulating Tumor DNA Assay for Molecular Residual Disease Monitoring of Solid Malignancies.MedComm · 2025Article
Corrections and comments
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging evidence suggests that minimal residual disease (MRD) monitoring in solid tumors has implications for prognosis, treatment response, and therapeutic intervention. However, detecting MRD requires highly sensitive and specific circulating tumor DNA (ctDNA) assays. Therefore, we developed an innovative MRD monitoring assay that offers superior performance and cost advantage. Our approach utilizes a comprehensive genomic profiling panel to characterize the patient-specific mutational landscape of tumor tissue and selects up to 20 top-ranked variants to design a personalized panel, which is integrated with a tumor-naive cancer-type-specific fixed panel for ultra-deep sequencing of plasma ctDNA to monitor MRD in common solid tumors. Its limit of detection at the sample level reaches as low as 0.005%, with a specificity of 100%. Furthermore, when applied to colorectal, breast, and lung cancer patients, the ctDNA-MRD assay accurately predicted postoperative recurrence, prior to radiographic imaging by a median of 112 days for breast cancer and 83 days for lung cancer. In the tracked variants, clonal mutations demonstrated superior prognostic value compared to subclonal variants. This personalized MRD monitoring assay has the potential to enhance early detection of residual or recurrent disease, enable patient prognostic stratification, and inform clinical decision-making for patients with common solid tumors.
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Registered trials
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