ArticleTransboundary and emerging diseases2025
Global Transmission and Evolution of Chikungunya Virus: Origins, Adaptive Mutations, and Intercontinental Spread of the Three Genotypes.
Article in Transboundary and emerging diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chikungunya virus (CHIKV) is an arthropod-borne virus that has caused several major outbreaks around the world and is becoming increasingly harmful. Although significant progress has been made in understanding the global epidemiology and transmission of CHIKV, a systematic description of the transmission history of its three genotypes is still lacking. To address this gap, this study integrates multiple bioinformatics approaches to explore their origin, evolution, and transmission dynamics. We analyzed publicly available CHIKV genomes from NCBI to elucidate the genetic evolution and transmission potential of these genotypes. Phylogeographic and molecular evolutionary analyses showed that the West African (WA) genotype originated in Nigeria and spread exclusively within Africa; the Eastern/Central/South African (ECSA) genotype originated in Tanzania and spread globally; and the Asian genotype originated in Thailand, spread throughout Asia, Oceania, and the Americas, exhibiting the highest evolutionary rate among the three genotypes. We also identified 15 positively selected sites and 10 nonconservative mutation sites with altered hydrophobicity across CHIKV proteins, all of which need further investigation into their effects on viral protein function. The data from this study are important for understanding the transmission history of the three genotypes of CHIKV, providing new targets for CHIKV antiviral therapy and ideas for developing effective prevention and control measures in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.